Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3727103..3727632 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag M1780_RS17515 Protein ID WP_003417760.1
Coordinates 3727375..3727632 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag M1780_RS17510 Protein ID WP_003417757.1
Coordinates 3727103..3727378 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS17475 (M1780_17470) 3723676..3724365 - 690 WP_003917774.1 BBE domain-containing protein -
M1780_RS17480 (M1780_17475) 3724552..3724923 - 372 WP_003417739.1 FAD-binding protein -
M1780_RS17485 (M1780_17480) 3724821..3725039 - 219 WP_157132559.1 hypothetical protein -
M1780_RS17490 (M1780_17485) 3725066..3725326 - 261 WP_003417741.1 hypothetical protein -
M1780_RS17495 (M1780_17490) 3725441..3725830 + 390 WP_010950876.1 DUF732 domain-containing protein -
M1780_RS17500 (M1780_17495) 3725844..3726137 - 294 WP_003417749.1 DUF3017 domain-containing protein -
M1780_RS17505 (M1780_17500) 3726134..3726979 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
M1780_RS17510 (M1780_17505) 3727103..3727378 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
M1780_RS17515 (M1780_17510) 3727375..3727632 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
M1780_RS17520 (M1780_17515) 3727674..3728864 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
M1780_RS17525 (M1780_17520) 3728981..3729349 + 369 WP_003417765.1 FHA domain-containing protein -
M1780_RS17530 (M1780_17525) 3729346..3729897 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
M1780_RS17535 (M1780_17530) 3729904..3730485 - 582 WP_003417769.1 ATP/GTP-binding protein -
M1780_RS17540 (M1780_17535) 3730466..3730834 - 369 WP_003417772.1 DUF742 domain-containing protein -
M1780_RS17545 (M1780_17540) 3730812..3731204 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T243608 WP_003417760.1 NZ_CP096840:3727375-3727632 [Mycobacterium tuberculosis variant bovis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T243608 NZ_OX419563:2165206-2165298 [Bacillus subtilis]
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT243608 WP_003417757.1 NZ_CP096840:3727103-3727378 [Mycobacterium tuberculosis variant bovis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT243608 NZ_OX419563:c2165452-2165279 [Bacillus subtilis]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References