Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3664985..3665659 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag M1780_RS17305 Protein ID WP_003417282.1
Coordinates 3664985..3665413 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag M1780_RS17310 Protein ID WP_003417286.1
Coordinates 3665417..3665659 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS17280 (M1780_17275) 3660807..3661208 - 402 WP_003417264.1 cytidine deaminase -
M1780_RS17285 (M1780_17280) 3661445..3661783 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
M1780_RS17290 (M1780_17285) 3661780..3662214 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
M1780_RS17295 (M1780_17290) 3662343..3664115 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
M1780_RS17300 (M1780_17295) 3664115..3664906 + 792 WP_010950870.1 succinate dehydrogenase iron-sulfur subunit -
M1780_RS17305 (M1780_17300) 3664985..3665413 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
M1780_RS17310 (M1780_17305) 3665417..3665659 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
M1780_RS17315 (M1780_17310) 3665781..3666395 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
M1780_RS17320 (M1780_17315) 3666392..3667057 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
M1780_RS17325 (M1780_17320) 3667058..3667591 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
M1780_RS17330 (M1780_17325) 3667588..3667962 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
M1780_RS17335 (M1780_17330) 3668059..3669063 - 1005 WP_003914475.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T243607 WP_003417282.1 NZ_CP096840:c3665413-3664985 [Mycobacterium tuberculosis variant bovis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T243607 NZ_OX419563:c1403685-1402939 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATTCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATATGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT243607 WP_003417286.1 NZ_CP096840:c3665659-3665417 [Mycobacterium tuberculosis variant bovis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT243607 NZ_OX419563:c1402939-1402769 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References