Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3136536..3137084 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag M1780_RS14920 Protein ID WP_003414602.1
Coordinates 3136821..3137084 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag M1780_RS14915 Protein ID WP_003414599.1
Coordinates 3136536..3136817 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS14890 (M1780_14885) 3132159..3133016 - 858 WP_273610396.1 type I methionyl aminopeptidase -
M1780_RS14895 (M1780_14890) 3133058..3133642 - 585 WP_010950792.1 DUF1707 domain-containing protein -
M1780_RS14900 (M1780_14895) 3133746..3133994 + 249 WP_003913411.1 antitoxin VapB23 -
M1780_RS14905 (M1780_14900) 3133991..3134371 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
M1780_RS14910 (M1780_14905) 3134453..3136264 - 1812 WP_003414596.1 penicillin-binding protein -
M1780_RS14915 (M1780_14910) 3136536..3136817 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
M1780_RS14920 (M1780_14915) 3136821..3137084 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1780_RS14925 (M1780_14920) 3137457..3138311 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
M1780_RS14930 (M1780_14925) 3138367..3139530 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
M1780_RS14935 (M1780_14930) 3139547..3140761 - 1215 WP_003414610.1 zinc metalloprotease Rip -
M1780_RS14940 (M1780_14935) 3140769..3142010 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T243604 WP_003414602.1 NZ_CP096840:3136821-3137084 [Mycobacterium tuberculosis variant bovis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T243604 NZ_OX419560:518114-518464 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT243604 WP_003414599.1 NZ_CP096840:3136536-3136817 [Mycobacterium tuberculosis variant bovis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT243604 NZ_OX419560:517828-518109 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References