Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 3028340..3029027 | Replicon | chromosome |
Accession | NZ_CP096840 | ||
Organism | Mycobacterium tuberculosis variant bovis strain Mb2269 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TF65 |
Locus tag | M1780_RS14345 | Protein ID | WP_003414064.1 |
Coordinates | 3028632..3029027 (-) | Length | 132 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TF64 |
Locus tag | M1780_RS14340 | Protein ID | WP_003414061.1 |
Coordinates | 3028340..3028606 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M1780_RS14315 (M1780_14310) | 3023979..3024881 | - | 903 | WP_003900564.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
M1780_RS14320 (M1780_14315) | 3024950..3025702 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
M1780_RS14325 (M1780_14325) | 3025946..3026221 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
M1780_RS14330 (M1780_14330) | 3026218..3027840 | - | 1623 | WP_003414057.1 | class I SAM-dependent DNA methyltransferase | - |
M1780_RS14335 (M1780_14335) | 3027927..3028343 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | - |
M1780_RS14340 (M1780_14340) | 3028340..3028606 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
M1780_RS14345 (M1780_14345) | 3028632..3029027 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
M1780_RS14350 (M1780_14350) | 3029024..3029293 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
M1780_RS14355 (M1780_14355) | 3029303..3030397 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
M1780_RS14360 (M1780_14360) | 3030394..3030813 | - | 420 | Protein_2833 | winged helix-turn-helix domain-containing protein | - |
M1780_RS14365 (M1780_14365) | 3030812..3030886 | + | 75 | Protein_2834 | hypothetical protein | - |
M1780_RS14370 (M1780_14370) | 3030887..3031366 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
M1780_RS14375 (M1780_14375) | 3031437..3032237 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
M1780_RS14380 (M1780_14380) | 3032393..3033130 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 132 a.a. Molecular weight: 14340.04 Da Isoelectric Point: 4.7145
>T243600 WP_003414064.1 NZ_CP096840:c3029027-3028632 [Mycobacterium tuberculosis variant bovis]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT
Download Length: 396 bp
>T243600 NZ_OX419557:c2211723-2211547 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA
GTGCTTGAGAAAGTGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT243600 WP_003414061.1 NZ_CP096840:c3028606-3028340 [Mycobacterium tuberculosis variant bovis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT243600 NZ_OX419557:2211664-2211764 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTACGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTACGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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