Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 2776134..2776786 | Replicon | chromosome |
Accession | NZ_CP096840 | ||
Organism | Mycobacterium tuberculosis variant bovis strain Mb2269 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TPX1 |
Locus tag | M1780_RS13015 | Protein ID | WP_003412752.1 |
Coordinates | 2776361..2776786 (+) | Length | 142 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P9WJ24 |
Locus tag | M1780_RS13010 | Protein ID | WP_003412749.1 |
Coordinates | 2776134..2776355 (+) | Length | 74 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M1780_RS12995 (M1780_12990) | 2774374..2774580 | - | 207 | WP_003899347.1 | hypothetical protein | - |
M1780_RS13000 (M1780_12995) | 2774716..2775339 | + | 624 | WP_003900858.1 | TIGR00725 family protein | - |
M1780_RS13005 (M1780_13000) | 2775329..2776081 | + | 753 | WP_003901416.1 | hypothetical protein | - |
M1780_RS13010 (M1780_13005) | 2776134..2776355 | + | 222 | WP_003412749.1 | antitoxin | Antitoxin |
M1780_RS13015 (M1780_13010) | 2776361..2776786 | + | 426 | WP_003412752.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
M1780_RS13020 (M1780_13015) | 2776809..2777990 | - | 1182 | WP_010950729.1 | dihydrolipoamide acetyltransferase family protein | - |
M1780_RS13025 (M1780_13020) | 2777987..2779033 | - | 1047 | WP_010950730.1 | 3-methyl-2-oxobutanoate dehydrogenase subunit beta | - |
M1780_RS13030 (M1780_13025) | 2779044..2780147 | - | 1104 | WP_003412761.1 | pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha | - |
M1780_RS13035 (M1780_13030) | 2780406..2781227 | - | 822 | WP_003412766.1 | citrate (pro-3S)-lyase subunit beta | - |
M1780_RS13040 (M1780_13035) | 2781224..2781781 | - | 558 | WP_273610387.1 | MaoC family dehydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 142 a.a. Molecular weight: 15392.89 Da Isoelectric Point: 9.2386
>T243593 WP_003412752.1 NZ_CP096840:2776361-2776786 [Mycobacterium tuberculosis variant bovis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL
Download Length: 426 bp
>T243593 NZ_OX419554:c2222292-2222116 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 7864.93 Da Isoelectric Point: 4.5258
>AT243593 WP_003412749.1 NZ_CP096840:2776134-2776355 [Mycobacterium tuberculosis variant bovis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED
Download Length: 222 bp
>AT243593 NZ_OX419554:2222233-2222333 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTATGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTATGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TPX1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BW03 |