Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2776134..2776786 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag M1780_RS13015 Protein ID WP_003412752.1
Coordinates 2776361..2776786 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag M1780_RS13010 Protein ID WP_003412749.1
Coordinates 2776134..2776355 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS12995 (M1780_12990) 2774374..2774580 - 207 WP_003899347.1 hypothetical protein -
M1780_RS13000 (M1780_12995) 2774716..2775339 + 624 WP_003900858.1 TIGR00725 family protein -
M1780_RS13005 (M1780_13000) 2775329..2776081 + 753 WP_003901416.1 hypothetical protein -
M1780_RS13010 (M1780_13005) 2776134..2776355 + 222 WP_003412749.1 antitoxin Antitoxin
M1780_RS13015 (M1780_13010) 2776361..2776786 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
M1780_RS13020 (M1780_13015) 2776809..2777990 - 1182 WP_010950729.1 dihydrolipoamide acetyltransferase family protein -
M1780_RS13025 (M1780_13020) 2777987..2779033 - 1047 WP_010950730.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
M1780_RS13030 (M1780_13025) 2779044..2780147 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
M1780_RS13035 (M1780_13030) 2780406..2781227 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
M1780_RS13040 (M1780_13035) 2781224..2781781 - 558 WP_273610387.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T243593 WP_003412752.1 NZ_CP096840:2776361-2776786 [Mycobacterium tuberculosis variant bovis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T243593 NZ_OX419554:c2222292-2222116 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT243593 WP_003412749.1 NZ_CP096840:2776134-2776355 [Mycobacterium tuberculosis variant bovis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT243593 NZ_OX419554:2222233-2222333 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTATGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References