Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2383888..2384417 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag M1780_RS11160 Protein ID WP_003411124.1
Coordinates 2383888..2384205 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag M1780_RS11165 Protein ID WP_003411127.1
Coordinates 2384202..2384417 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS11130 (M1780_11130) 2378909..2379985 + 1077 WP_003411110.1 hypothetical protein -
M1780_RS11135 (M1780_11135) 2379982..2380263 + 282 WP_003411112.1 DUF5703 family protein -
M1780_RS11140 (M1780_11140) 2380299..2381372 + 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
M1780_RS11145 (M1780_11145) 2381377..2381907 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
M1780_RS11150 (M1780_11150) 2381955..2383301 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
M1780_RS11160 (M1780_11160) 2383888..2384205 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1780_RS11165 (M1780_11165) 2384202..2384417 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
M1780_RS11170 (M1780_11170) 2384672..2385730 + 1059 WP_003411129.1 phosphoribosyltransferase family protein -
M1780_RS11175 (M1780_11175) 2385860..2386216 - 357 WP_003411130.1 hypothetical protein -
M1780_RS11180 (M1780_11180) 2386311..2387093 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
M1780_RS11185 (M1780_11185) 2387361..2387651 - 291 WP_003900476.1 YggT family protein -
M1780_RS11190 (M1780_11190) 2387813..2388469 - 657 WP_003411133.1 cell division protein SepF -
M1780_RS11195 (M1780_11195) 2388535..2389311 - 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T243592 WP_003411124.1 NZ_CP096840:c2384205-2383888 [Mycobacterium tuberculosis variant bovis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T243592 NZ_OX419554:c2222292-2222116 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT243592 WP_003411127.1 NZ_CP096840:c2384417-2384202 [Mycobacterium tuberculosis variant bovis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT243592 NZ_OX419554:2222075-2222175 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References