Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2207873..2208561 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag M1780_RS10335 Protein ID WP_003409958.1
Coordinates 2207873..2208292 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag M1780_RS10340 Protein ID WP_003409968.1
Coordinates 2208301..2208561 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS10305 (M1780_10305) 2202879..2203184 + 306 Protein_2036 ABC transporter permease -
M1780_RS10310 (M1780_10310) 2203180..2203260 + 81 Protein_2037 hypothetical protein -
M1780_RS10315 (M1780_10315) 2203368..2204216 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
M1780_RS10320 (M1780_10320) 2204179..2205624 - 1446 WP_273610367.1 APC family permease -
M1780_RS10325 (M1780_10325) 2205803..2206489 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
M1780_RS10330 (M1780_10330) 2206680..2207648 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
M1780_RS10335 (M1780_10335) 2207873..2208292 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
M1780_RS10340 (M1780_10340) 2208301..2208561 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1780_RS10345 (M1780_10345) 2208704..2210380 + 1677 WP_010950639.1 PecA family PE domain-processing aspartic protease -
M1780_RS10350 (M1780_10350) 2210368..2211021 - 654 WP_003409976.1 cutinase Cfp21 -
M1780_RS10355 (M1780_10355) 2211136..2211366 + 231 WP_003409980.1 DUF167 domain-containing protein -
M1780_RS10360 (M1780_10360) 2211451..2212362 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
M1780_RS10365 (M1780_10365) 2212471..2213070 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T243586 WP_003409958.1 NZ_CP096840:c2208292-2207873 [Mycobacterium tuberculosis variant bovis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T243586 NZ_OX419553:1904102-1904278 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT243586 WP_003409968.1 NZ_CP096840:c2208561-2208301 [Mycobacterium tuberculosis variant bovis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT243586 NZ_OX419553:c1904161-1904061 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTATGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References