Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2198859..2199403 | Replicon | chromosome |
| Accession | NZ_CP096840 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb2269 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | M1780_RS10275 | Protein ID | WP_003409896.1 |
| Coordinates | 2198859..2199155 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | M1780_RS10280 | Protein ID | WP_003409899.1 |
| Coordinates | 2199152..2199403 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1780_RS10220 (M1780_10220) | 2193892..2194242 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| M1780_RS10225 (M1780_10225) | 2194253..2195155 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| M1780_RS10230 (M1780_10230) | 2195176..2195367 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| M1780_RS10235 (M1780_10235) | 2195368..2195664 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| M1780_RS10240 (M1780_10240) | 2195904..2196119 | + | 216 | WP_003409878.1 | antitoxin | - |
| M1780_RS10245 (M1780_10245) | 2196116..2196427 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1780_RS10250 (M1780_10250) | 2196401..2196922 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| M1780_RS10255 (M1780_10255) | 2196897..2197274 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| M1780_RS10260 (M1780_10260) | 2197316..2197765 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| M1780_RS10265 (M1780_10265) | 2197762..2198307 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| M1780_RS10270 (M1780_10270) | 2198196..2198810 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| M1780_RS10275 (M1780_10275) | 2198859..2199155 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| M1780_RS10280 (M1780_10280) | 2199152..2199403 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| M1780_RS10285 (M1780_10285) | 2199390..2199884 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| M1780_RS10290 (M1780_10290) | 2200044..2200451 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1780_RS10295 (M1780_10295) | 2200455..2200727 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| M1780_RS10300 (M1780_10300) | 2200760..2201980 | - | 1221 | WP_273610366.1 | TetR family transcriptional regulator Mce3R | - |
| M1780_RS10305 (M1780_10305) | 2202879..2203184 | + | 306 | Protein_2036 | ABC transporter permease | - |
| M1780_RS10310 (M1780_10310) | 2203180..2203260 | + | 81 | Protein_2037 | hypothetical protein | - |
| M1780_RS10315 (M1780_10315) | 2203368..2204216 | + | 849 | WP_003409942.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T243585 WP_003409896.1 NZ_CP096840:c2199155-2198859 [Mycobacterium tuberculosis variant bovis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T243585 NZ_OX419553:c1853449-1853333 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT243585 WP_003409899.1 NZ_CP096840:c2199403-2199152 [Mycobacterium tuberculosis variant bovis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT243585 NZ_OX419553:1853160-1853338 [Bacillus subtilis]
AATGATACAAATAATTATTTTTTGCATTTTGATTTGTAGAAATGCATAAAATAAAAAGACCAGGGTGCTACCAACACCCC
AGCTCTGTACAAAAAGCTGCCCATCAAAGGGCTTGCTCAGATGTATGTGACATAGTAGACCAACCCTTTAGGGTCGCAAT
CTCAAGGGGAGGTCTATTT
AATGATACAAATAATTATTTTTTGCATTTTGATTTGTAGAAATGCATAAAATAAAAAGACCAGGGTGCTACCAACACCCC
AGCTCTGTACAAAAAGCTGCCCATCAAAGGGCTTGCTCAGATGTATGTGACATAGTAGACCAACCCTTTAGGGTCGCAAT
CTCAAGGGGAGGTCTATTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |