Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1934820..1935433 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag M1780_RS09055 Protein ID WP_003408465.1
Coordinates 1934820..1935209 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag M1780_RS09060 Protein ID WP_003408469.1
Coordinates 1935206..1935433 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS09020 (M1780_09020) 1930450..1931364 + 915 WP_273610482.1 3-hydroxyacyl-CoA dehydrogenase family protein -
M1780_RS09025 (M1780_09025) 1931367..1932197 + 831 WP_003408448.1 cyclase family protein -
M1780_RS09030 (M1780_09030) 1932197..1932547 + 351 WP_003898986.1 cupin domain-containing protein -
M1780_RS09035 (M1780_09035) 1932600..1933417 + 818 Protein_1783 3-keto-5-aminohexanoate cleavage protein -
M1780_RS09040 (M1780_09040) 1933431..1934210 + 780 WP_003408460.1 IclR family transcriptional regulator -
M1780_RS09050 (M1780_09050) 1934641..1934772 + 132 Protein_1785 IS3 family transposase -
M1780_RS09055 (M1780_09055) 1934820..1935209 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
M1780_RS09060 (M1780_09060) 1935206..1935433 - 228 WP_003408469.1 antitoxin Antitoxin
M1780_RS09065 (M1780_09065) 1935651..1937135 + 1485 WP_010950580.1 biotin carboxylase -
M1780_RS09070 (M1780_09070) 1937132..1938379 + 1248 WP_003408476.1 serine hydrolase -
M1780_RS09075 (M1780_09075) 1938422..1938841 - 420 WP_003408483.1 hypothetical protein -
M1780_RS09080 (M1780_09080) 1938831..1939541 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T243581 WP_003408465.1 NZ_CP096840:c1935209-1934820 [Mycobacterium tuberculosis variant bovis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T243581 NZ_OX419551:2093282-2093374 [Bacillus subtilis]
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT243581 WP_003408469.1 NZ_CP096840:c1935433-1935206 [Mycobacterium tuberculosis variant bovis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT243581 NZ_OX419551:c2093528-2093355 [Bacillus subtilis]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References