Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1229360..1229991 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag M1780_RS05890 Protein ID WP_003405820.1
Coordinates 1229360..1229671 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag M1780_RS05895 Protein ID WP_003405836.1
Coordinates 1229671..1229991 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS05870 (M1780_05870) 1224842..1226266 - 1425 WP_003405805.1 class II fumarate hydratase -
M1780_RS05875 (M1780_05875) 1226297..1227385 - 1089 WP_273610472.1 class II fructose-bisphosphatase -
M1780_RS05880 (M1780_05880) 1227441..1228085 + 645 WP_003915494.1 DUF4245 domain-containing protein -
M1780_RS05885 (M1780_05885) 1228092..1229248 - 1157 Protein_1159 AI-2E family transporter -
M1780_RS05890 (M1780_05890) 1229360..1229671 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
M1780_RS05895 (M1780_05895) 1229671..1229991 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
M1780_RS05900 (M1780_05900) 1230001..1231537 + 1537 Protein_1162 carboxylesterase/lipase family protein -
M1780_RS05905 (M1780_05905) 1231544..1232656 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
M1780_RS05910 (M1780_05910) 1232666..1232923 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
M1780_RS05915 (M1780_05915) 1232913..1234160 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
M1780_RS05920 (M1780_05920) 1234157..1234795 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T243573 WP_003405820.1 NZ_CP096840:c1229671-1229360 [Mycobacterium tuberculosis variant bovis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

>T243573 NZ_OX411212:2037815-2038105 [Vibrio campbellii]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAACTATCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT243573 WP_003405836.1 NZ_CP096840:c1229991-1229671 [Mycobacterium tuberculosis variant bovis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp

>AT243573 NZ_OX411212:2037577-2037825 [Vibrio campbellii]
ATGACCACTAGAATTTTAGCCGATGTCGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTATTAAACCGAAATGAACCGGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References