Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 1021834..1022807 | Replicon | chromosome |
Accession | NZ_CP096840 | ||
Organism | Mycobacterium tuberculosis variant bovis strain Mb2269 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | O05911 |
Locus tag | M1780_RS04870 | Protein ID | WP_003404756.1 |
Coordinates | 1022307..1022807 (+) | Length | 167 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | G0TFR4 |
Locus tag | M1780_RS04865 | Protein ID | WP_003404754.1 |
Coordinates | 1021834..1022310 (+) | Length | 159 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M1780_RS04845 (M1780_04845) | 1017681..1018952 | - | 1272 | WP_003404747.1 | PPE family protein | - |
M1780_RS04850 (M1780_04850) | 1018967..1019266 | - | 300 | WP_003404748.1 | PE family protein | - |
M1780_RS04855 (M1780_04855) | 1019710..1021491 | + | 1782 | WP_003404749.1 | BCCT family transporter | - |
M1780_RS04860 (M1780_04860) | 1021491..1021745 | + | 255 | WP_003898646.1 | hypothetical protein | - |
M1780_RS04865 (M1780_04865) | 1021834..1022310 | + | 477 | WP_003404754.1 | DUF1778 domain-containing protein | Antitoxin |
M1780_RS04870 (M1780_04870) | 1022307..1022807 | + | 501 | WP_003404756.1 | GNAT family N-acetyltransferase | Toxin |
M1780_RS04880 (M1780_04880) | 1023120..1024439 | - | 1320 | WP_010950468.1 | IS256-like element IS1554 family transposase | - |
M1780_RS04885 (M1780_04885) | 1024727..1025308 | + | 582 | WP_003404760.1 | IS607-like element IS1535 family transposase | - |
M1780_RS04890 (M1780_04890) | 1025308..1026960 | + | 1653 | WP_003404761.1 | IS607 family element RNA-guided endonuclease TnpB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 167 a.a. Molecular weight: 18048.55 Da Isoelectric Point: 7.8659
>T243571 WP_003404756.1 NZ_CP096840:1022307-1022807 [Mycobacterium tuberculosis variant bovis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
Download Length: 501 bp
>T243571 NZ_OX411212:c1563044-1562766 [Vibrio campbellii]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGGGTACAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTCTCTTACTGGATTGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGGGTACAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTCTCTTACTGGATTGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA
Antitoxin
Download Length: 159 a.a. Molecular weight: 17357.95 Da Isoelectric Point: 11.2467
>AT243571 WP_003404754.1 NZ_CP096840:1021834-1022310 [Mycobacterium tuberculosis variant bovis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
Download Length: 477 bp
>AT243571 NZ_OX411212:c1563325-1563041 [Vibrio campbellii]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TCTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSZ2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TFR4 |