Detailed information of TA system TA243570

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1012304..1012923
• Replicon: chromosome
• Accession: NZ_CP096840
• Organism: Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: M1780_RS04815
• Protein ID: WP_003404726.1
• Coordinates: 1012489..1012923 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: G0TFQ5
• Locus tag: M1780_RS04810
• Protein ID: WP_003404724.1
• Coordinates: 1012304..1012483 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1780_RS04795 (M1780_04795)	1007777..1009357	+	1581	WP_011799139.1	serine hydrolase	-
M1780_RS04800 (M1780_04800)	1009354..1011747	+	2394	WP_003898639.1	cation-translocating P-type ATPase	-
M1780_RS04805 (M1780_04805)	1012020..1012178	+	159	WP_003404720.1	hypothetical protein	-
M1780_RS04810 (M1780_04810)	1012304..1012483	+	180	WP_003404724.1	antitoxin	Antitoxin
M1780_RS04815 (M1780_04815)	1012489..1012923	+	435	WP_003404726.1	SRPBCC family protein	Toxin
M1780_RS04820 (M1780_04820)	1013021..1013794	+	774	WP_003404735.1	VOC family protein	-
M1780_RS04825 (M1780_04825)	1013859..1014308	+	450	WP_003404738.1	hypothetical protein	-
M1780_RS04830 (M1780_04830)	1014443..1014673	-	231	WP_003898642.1	hypothetical protein	-
M1780_RS04835 (M1780_04835)	1014840..1016348	-	1509	WP_003404742.1	carotenoid oxygenase family protein	-
M1780_RS04840 (M1780_04840)	1016350..1017588	-	1239	WP_003404744.1	acetyl-CoA acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-50)

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15754.47 Da
• Isoelectric Point: 9.7977

>T243570 WP_003404726.1 NZ_CP096840:1012489-1012923 [Mycobacterium tuberculosis variant bovis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Nucleotide

• Length: 435 bp

>T243570 NZ_OX411212:c1535865-1535575 [Vibrio campbellii]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGCTCGACTCTACAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAGCTTTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTTGTCTACAAAGTTGAAGATGATGTCATCATTGTAACCGTCTTAGCAGTCGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAGGCCATGAAAAGATTAGATGATTGA

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6394.06 Da
• Isoelectric Point: 4.3059

>AT243570 WP_003404724.1 NZ_CP096840:1012304-1012483 [Mycobacterium tuberculosis variant bovis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS

Nucleotide

• Length: 180 bp

>AT243570 NZ_OX411212:c1536103-1535855 [Vibrio campbellii]
ATGGCCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACCGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTTGCTGTACTAAACCGAAATGAGCCGGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTATTAGCTATTGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Structures

Antitoxin

• AlphaFold DB: G0TFQ5