Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 716249..716913 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name vapC Uniprot ID P96917
Locus tag M1780_RS03300 Protein ID WP_003403246.1
Coordinates 716506..716913 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF18
Locus tag M1780_RS03295 Protein ID WP_003403244.1
Coordinates 716249..716509 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS03270 (M1780_03270) 712426..713583 + 1158 WP_003903091.1 hypothetical protein -
M1780_RS03275 (M1780_03275) 713594..714541 + 948 WP_003403232.1 DUF732 domain-containing protein -
M1780_RS03280 (M1780_03280) 714634..714888 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 -
M1780_RS03285 (M1780_03285) 714888..715283 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 -
M1780_RS03290 (M1780_03290) 715377..716117 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
M1780_RS03295 (M1780_03295) 716249..716509 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M1780_RS03300 (M1780_03300) 716506..716913 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin Toxin
M1780_RS03305 (M1780_03305) 716985..718136 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
M1780_RS03310 (M1780_03310) 718229..719956 - 1728 WP_010950423.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14376.37 Da        Isoelectric Point: 4.3568

>T243564 WP_003403246.1 NZ_CP096840:716506-716913 [Mycobacterium tuberculosis variant bovis]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Download         Length: 408 bp

>T243564 NZ_OX359243:3266066-3266659 [Alteromonas macleodii]
GTGCATCGCAATAATATCCCGTGGATATTAGATAATGGTCTTTATTGTGGTAATAGCCATGTCCAGTCACCTAATTGGGA
GGCCATAGGTAATTCGGAACTCATACAGAAACGCGCCACTCACCCAGTCCCCATATCACCATTTGGCTCTTTAAATGACT
ATGTGCCTTTCTATTTTACCCCGTTTTCCCCCATGTTGCTCAATATCAAGTCTGGACGGGGGGTTAAGCAGAGGGCTAAC
GAAGATATCGTTATATTGGTATCATCATTACACAAAGTTGAACAACTAAACTTAGATTTTGTCTATACGGACATGCATGC
ATATTATCAGTGGGCGAGTTTTTACTCGGATTTGAATCACTTGGGTGAAGTAGATTGGCCTATATTACAAACGCGGAATT
TTGCCAGAGATCTCAACGACCCAGCCAAGTTTGAACGATATCAAGCAGAAGCATTGGTAAAGCAGCATTGTCCAATAAAT
GCTTTAGTAGGTATAGCTTGTTACAATACTCGAGTTGAACAAGAGTTAAAACATCATATTCAACAGCGCAATATGAATTT
AGACGTAATTGTACGTCCAGGATGGTACTTCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9492.84 Da        Isoelectric Point: 11.9108

>AT243564 WP_003403244.1 NZ_CP096840:716249-716509 [Mycobacterium tuberculosis variant bovis]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR

Download         Length: 261 bp

>AT243564 NZ_OX359243:3266659-3267723 [Alteromonas macleodii]
ATGATCACTTATACGCAAGGTAATTTACTCGAAGCACAAGTAGAGGCACTCGTTAACACTGTAAATACAGTTGGAGTTAT
GGGGAAAGGTATTGCACTAATGTTCAAAGAGCGCTTTCCCAAAAACATGGCTGAATATGCTAGTGCTTGCAAAGCTAAGC
AGGTAAATACAGGTAAAATGTTTGTTACTGAAACTAGTGAGTTGATGGGTCCTAAGTGGATTGTTAATTTTCCTACTAAG
CAGCATTGGCGTGCAAAATCTAAAATGGAGTGGATCCAAGAGGGCTTAATCGATCTTCGATATTTCTTAGAAAACAACAA
TGTCCGATCAATAGCTATTCCGCCACTTGGTGCGGGACAGGGTGGACTAGCCTGGCCAGATGTAAAAATGGAGATCGAAA
AGGCTTTATCAGACATTAAAACCACAAATATTATTGTGTTTGAGCCTACCAGTAAATATCAAAACGTGGCCAAGGCATCA
GGTGTTAAGAAACTTACTCCAGCGCGAGCATTAGTTGCAGAATTAGTGAGGCGCTATTGGATTTTGGGTATGGAATGTAG
TTTGTTGGAGATTCAAAAACTCGCTTGGTTTTTACAAAGAACAATCGAAAAAAGAGGGTTAAAAAACGAATTAAAACTGA
AATTTGAAGCAAATTATTATGGACCATATGCCAATAATCTAGACCATTTACTAAATGCTCTAGATGGTAGTTATTTGAAA
TCTGATAAACGAATTCCTGATTGCGACCCGTTGGATGTGATTTGGTTTAATGAATCAGAAAAGCAAAAAATTTCAACGTA
CTTGAATACAGAAGCCAAAGAATATTTACCCGCACTCGAGGGCGCAACTCAAGTAATCAGCGGTTTCGAATCCCCTTTTG
GTTTAGAGCTTCTATCTACAGTAGATTGGTTAGTTACTAACCAAGGCTGTGAAAGGACTGTTGAATCTATTAAAGAAGGT
ATAGCTAATTGGCCTGCTGGAGCTAAATGGGCGCAAAGAAAATTTAACTTATTTAGCAATAAAGATATTGAATTTGCTTT
AACTAATTTGGAAATTCTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3DBO

Antitoxin

Source ID Structure
PDB 3DBO
AlphaFold DB A0A7U4BSE4

References