Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 714634..715283 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag M1780_RS03285 Protein ID WP_003403236.1
Coordinates 714888..715283 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag M1780_RS03280 Protein ID WP_003403235.1
Coordinates 714634..714888 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS03255 (M1780_03255) 709759..709842 + 84 Protein_645 galactose-1-phosphate uridylyltransferase -
M1780_RS03260 (M1780_03260) 709861..710943 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
M1780_RS03265 (M1780_03265) 710940..712031 + 1092 WP_003403225.1 galactokinase -
M1780_RS03270 (M1780_03270) 712426..713583 + 1158 WP_003903091.1 hypothetical protein -
M1780_RS03275 (M1780_03275) 713594..714541 + 948 WP_003403232.1 DUF732 domain-containing protein -
M1780_RS03280 (M1780_03280) 714634..714888 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
M1780_RS03285 (M1780_03285) 714888..715283 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
M1780_RS03290 (M1780_03290) 715377..716117 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
M1780_RS03295 (M1780_03295) 716249..716509 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M1780_RS03300 (M1780_03300) 716506..716913 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
M1780_RS03305 (M1780_03305) 716985..718136 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
M1780_RS03310 (M1780_03310) 718229..719956 - 1728 WP_010950423.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T243563 WP_003403236.1 NZ_CP096840:714888-715283 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T243563 NZ_OX359243:c2125742-2125425 [Alteromonas macleodii]
ATGGCACAGTTTGATGTTTACAGAAACCCAAGCTCAAAAACAAATAGAGCTTACCCCTTTCTTGTAGATGTTCAAAACTC
TGTAATTGACCAATTAGCAACAAGGTTAGTTGTACCGCTGACAAAGAATAAGACTACAAATAGTCTTTATATGAAAAATC
TTACGCCGGAGATAGAATTCGAAGGCGAGACATACCTATTCGTGACTCAACAACTTAGTTCCTTACCCGAAGATGTGCTC
AAGGACTGCATCGGTTCTTTGGCGCAATCCCGTGAATTGCTAATAGGTGCAATAGACTTTGCTATTACTGGAATATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT243563 WP_003403235.1 NZ_CP096840:714634-714888 [Mycobacterium tuberculosis variant bovis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT243563 NZ_OX359243:c2125987-2125742 [Alteromonas macleodii]
ATGCAAGATTTATATGACATTCATGCCCCAAAAAAAGCGACTAACTTAAGCTTGAACAGCGACTTATTACAAAAAGCTAG
AGACTTAAAAGTTAACCTGTCTGCAACTTTAGAACAGGCACTTAAAGACAAGTTGAAAAGTGTTGAAGAAGAAAGGTGGA
AAAAAGAAAACAAAGCTGCCATAGCTGCCTACAACGAGTTTGTTGCTGAGAACGGCTGTATAGGTGATGAGTACAGGAAC
TTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References