Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 709005..709630 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag M1780_RS03250 Protein ID WP_003403218.1
Coordinates 709229..709630 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag M1780_RS03245 Protein ID WP_003403213.1
Coordinates 709005..709232 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS03220 (M1780_03220) 704184..704405 - 222 WP_003898525.1 DUF4926 domain-containing protein -
M1780_RS03225 (M1780_03225) 704547..705152 + 606 WP_003898526.1 hypothetical protein -
M1780_RS03230 (M1780_03230) 705171..707738 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
M1780_RS03235 (M1780_03235) 707822..708571 + 750 WP_003898528.1 hypothetical protein -
M1780_RS03240 (M1780_03240) 708568..708810 + 243 WP_003403210.1 hypothetical protein -
M1780_RS03245 (M1780_03245) 709005..709232 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
M1780_RS03250 (M1780_03250) 709229..709630 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
M1780_RS03255 (M1780_03255) 709759..709842 + 84 Protein_645 galactose-1-phosphate uridylyltransferase -
M1780_RS03260 (M1780_03260) 709861..710943 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
M1780_RS03265 (M1780_03265) 710940..712031 + 1092 WP_003403225.1 galactokinase -
M1780_RS03270 (M1780_03270) 712426..713583 + 1158 WP_003903091.1 hypothetical protein -
M1780_RS03275 (M1780_03275) 713594..714541 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T243562 WP_003403218.1 NZ_CP096840:709229-709630 [Mycobacterium tuberculosis variant bovis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T243562 NZ_OX359241:c2915558-2915157 [Alteromonas macleodii]
ATGGAGCTTATTTTTTTCCCCTTCGAGCGCGTTATAGAGATTAACGCCTACATTCTCGAAAACGAGCCTGGTATGAAGGG
GGCCGCTGATATCAATAAGCTTCAGGGGGCGCTAGGCAGGATTGATAATGCTATTGTTTATTTAGGCTTGAATGATGTTT
TCGAAATAGCAGCAAAGTATGCTTCCTCTATTGCACTTTCTCATTCGCTTCCTGATGCAAACAAACGGACTGGTCTCGCT
GTAGCTTTGGAATATTTATCTCTCAATGATTATGAATTAATTGCTGATAACGAATTATTCGCAGATGCCATCAGAGATTT
GGTTGTGGGCAAAATTGGTGAAGCGGATTTTGCTGACCTTCTTTATGCTCAGTATATTTCTGAACAAAATCAAAATAGTT
AA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT243562 WP_003403213.1 NZ_CP096840:709005-709232 [Mycobacterium tuberculosis variant bovis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT243562 NZ_OX359241:c2915728-2915558 [Alteromonas macleodii]
ATGAATACAAAAATTGAAGTTTACGGTGTTAAAGCTGTTCAACGCCCCAAAGTTCCAGCAAGAAAGAAACTTGACCTCTC
TGGTGAGTTTGGGCAACAGATCGTGAAATCCGAAACTAAGCTAGTGCTAAGAACACACAAGCGTACGTTCGAAAAACTCG
CTTACATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References