Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 442317..443328 Replicon chromosome
Accession NZ_CP096840
Organism Mycobacterium tuberculosis variant bovis strain Mb2269

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag M1780_RS01935 Protein ID WP_003401859.1
Coordinates 442317..442910 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag M1780_RS01940 Protein ID WP_003401860.1
Coordinates 442939..443328 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1780_RS01915 (M1780_01915) 437966..439348 + 1383 WP_003898415.1 magnesium transporter -
M1780_RS01920 (M1780_01920) 439360..440394 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
M1780_RS01925 (M1780_01925) 440490..441173 + 684 WP_010950388.1 VTT domain-containing protein -
M1780_RS01930 (M1780_01930) 441162..442292 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
M1780_RS01935 (M1780_01935) 442317..442910 - 594 WP_003401859.1 zeta toxin family protein Toxin
M1780_RS01940 (M1780_01940) 442939..443328 - 390 WP_003401860.1 hypothetical protein Antitoxin
M1780_RS01945 (M1780_01945) 443409..444620 - 1212 WP_273610450.1 VWA domain-containing protein -
M1780_RS01950 (M1780_01950) 444626..445228 - 603 WP_003898417.1 SRPBCC family protein -
M1780_RS01955 (M1780_01955) 445242..446138 - 897 WP_003401863.1 MoxR family ATPase -
M1780_RS01960 (M1780_01960) 446135..446728 - 594 WP_003401864.1 NTP transferase domain-containing protein -
M1780_RS01965 (M1780_01965) 446725..447480 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T243557 WP_003401859.1 NZ_CP096840:c442910-442317 [Mycobacterium tuberculosis variant bovis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T243557 NZ_OX359239:c2212632-2212315 [Alteromonas macleodii]
ATGGCACAGTTTGATGTTTACAGAAACCCAAGCTCAAAAACAAATAGAGCTTACCCCTTTCTTGTAGATGTTCAAAACTC
TGTAATTGACCAATTAGCAACAAGGTTAGTTGTACCGCTGACAAAGAATAAGACTACAAATAGTCTTTATATGAAAAATC
TTACGCCGGAGATAGAATTCGAAGGCGAGACATACCTATTCGTGACTCAACAACTTAGTTCCTTACCCGAAGATGTGCTC
AAGGACTGCATCGGTTCTTTGGCGCAATCCCGTGAATTGCTAATAGGTGCAATAGACTTTGCTATTACTGGAATATAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT243557 WP_003401860.1 NZ_CP096840:c443328-442939 [Mycobacterium tuberculosis variant bovis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT243557 NZ_OX359239:c2212877-2212632 [Alteromonas macleodii]
ATGCAAGATTTATATGACATTCATGCCCCAAAAAAAGCGACTAACTTAAGCTTGAACAGCGACTTATTACAAAAAGCTAG
AGACTTAAAAGTTAACCTGTCTGCAACTTTAGAACAGGCACTTAAAGACAAGTTGAAAAGTGTTGAAGAAGAAAGGTGGA
AAAAAGAAAACAAAGCTGCCATAGCTGCCTACAACGAGTTTGTTGCTGAGAACGGCTGTATAGGTGATGAGTACAGGAAC
TTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References