Detailed information of TA system TA243552

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 3783078..3783763
• Replicon: chromosome
• Accession: NZ_CP096839
• Organism: Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TIR9
• Locus tag: M1779_RS17760
• Protein ID: WP_003417998.1
• Coordinates: 3783353..3783763 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: M1779_RS17755
• Protein ID: WP_003912220.1
• Coordinates: 3783078..3783356 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1779_RS17735 (M1779_17735)	3779067..3780668	-	1602	WP_003417969.1	FAD/NAD(P)-binding protein	-
M1779_RS17740 (M1779_17740)	3780685..3781389	-	705	WP_003417980.1	dTDP-4-amino-4,6-dideoxyglucose formyltransferase	-
M1779_RS17745 (M1779_17745)	3781507..3782073	-	567	WP_003417984.1	TetR/AcrR family transcriptional regulator	-
M1779_RS17750 (M1779_17750)	3782135..3783022	+	888	WP_003900050.1	alpha-ketoglutarate-dependent sulfate ester dioxygenase	-
M1779_RS17755 (M1779_17755)	3783078..3783356	+	279	WP_003912220.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
M1779_RS17760 (M1779_17760)	3783353..3783763	+	411	WP_003417998.1	type II toxin-antitoxin system VapC family toxin	Toxin
M1779_RS17765 (M1779_17765)	3783796..3785532	-	1737	WP_003418002.1	cholesterol oxidase	-
M1779_RS17770 (M1779_17770)	3785588..3786715	-	1128	WP_003418005.1	GuaB3 family IMP dehydrogenase-related protein	-
M1779_RS17775 (M1779_17775)	3786735..3788324	-	1590	WP_003900682.1	IMP dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-118)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-54)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14695.84 Da
• Isoelectric Point: 5.1784

>T243552 WP_003417998.1 NZ_CP096839:3783353-3783763 [Mycobacterium tuberculosis variant bovis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Nucleotide

• Length: 411 bp

>T243552 NZ_OX359183:37962-38444 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10280.75 Da
• Isoelectric Point: 10.1819

>AT243552 WP_003912220.1 NZ_CP096839:3783078-3783356 [Mycobacterium tuberculosis variant bovis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Nucleotide

• Length: 279 bp

>AT243552 NZ_OX359183:37708-37974 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: G0TIR9