Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3666393..3667067 Replicon chromosome
Accession NZ_CP096839
Organism Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag M1779_RS17305 Protein ID WP_003417282.1
Coordinates 3666393..3666821 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag M1779_RS17310 Protein ID WP_003417286.1
Coordinates 3666825..3667067 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1779_RS17280 (M1779_17280) 3662215..3662616 - 402 WP_003417264.1 cytidine deaminase -
M1779_RS17285 (M1779_17285) 3662853..3663191 + 339 WP_003417267.1 succinate dehydrogenase, cytochrome b556 subunit -
M1779_RS17290 (M1779_17290) 3663188..3663622 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
M1779_RS17295 (M1779_17295) 3663751..3665523 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
M1779_RS17300 (M1779_17300) 3665523..3666314 + 792 WP_010950870.1 succinate dehydrogenase iron-sulfur subunit -
M1779_RS17305 (M1779_17305) 3666393..3666821 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
M1779_RS17310 (M1779_17310) 3666825..3667067 - 243 WP_003417286.1 CopG family transcriptional regulator Antitoxin
M1779_RS17315 (M1779_17315) 3667189..3667803 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
M1779_RS17320 (M1779_17320) 3667800..3668465 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
M1779_RS17325 (M1779_17325) 3668466..3668999 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
M1779_RS17330 (M1779_17330) 3668996..3669370 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
M1779_RS17335 (M1779_17335) 3669467..3670471 - 1005 WP_003914475.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T243549 WP_003417282.1 NZ_CP096839:c3666821-3666393 [Mycobacterium tuberculosis variant bovis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T243549 NZ_OX359182:c3770344-3770126 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT243549 WP_003417286.1 NZ_CP096839:c3667067-3666825 [Mycobacterium tuberculosis variant bovis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT243549 NZ_OX359182:c3770745-3770371 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References