Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3139950..3140498 Replicon chromosome
Accession NZ_CP096839
Organism Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag M1779_RS14945 Protein ID WP_003414602.1
Coordinates 3140235..3140498 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag M1779_RS14940 Protein ID WP_003414599.1
Coordinates 3139950..3140231 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1779_RS14915 (M1779_14915) 3135573..3136430 - 858 WP_003899513.1 type I methionyl aminopeptidase -
M1779_RS14920 (M1779_14920) 3136472..3137056 - 585 WP_010950792.1 DUF1707 domain-containing protein -
M1779_RS14925 (M1779_14925) 3137160..3137408 + 249 WP_003913411.1 antitoxin VapB23 -
M1779_RS14930 (M1779_14930) 3137405..3137785 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
M1779_RS14935 (M1779_14935) 3137867..3139678 - 1812 WP_003414596.1 penicillin-binding protein -
M1779_RS14940 (M1779_14940) 3139950..3140231 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
M1779_RS14945 (M1779_14945) 3140235..3140498 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1779_RS14950 (M1779_14950) 3140871..3141725 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
M1779_RS14955 (M1779_14955) 3141781..3142944 - 1164 WP_044291354.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
M1779_RS14960 (M1779_14960) 3142961..3144175 - 1215 WP_003414610.1 zinc metalloprotease Rip -
M1779_RS14965 (M1779_14965) 3144183..3145424 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T243546 WP_003414602.1 NZ_CP096839:3140235-3140498 [Mycobacterium tuberculosis variant bovis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T243546 NZ_OX359182:3005370-3005654 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT243546 WP_003414599.1 NZ_CP096839:3139950-3140231 [Mycobacterium tuberculosis variant bovis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT243546 NZ_OX359182:3005138-3005380 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGGTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References