Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2841725..2842356 Replicon chromosome
Accession NZ_CP096839
Organism Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag M1779_RS13345 Protein ID WP_003413174.1
Coordinates 2841979..2842356 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag M1779_RS13340 Protein ID WP_003413167.1
Coordinates 2841725..2841982 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1779_RS13310 (M1779_13310) 2837639..2837953 + 315 WP_009937839.1 hypothetical protein -
M1779_RS13315 (M1779_13315) 2838249..2839460 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
M1779_RS13320 (M1779_13320) 2839587..2840246 + 660 WP_003900846.1 LppA family lipoprotein -
M1779_RS13325 (M1779_13325) 2840243..2840905 + 663 WP_003900848.1 LppA family lipoprotein -
M1779_RS13330 (M1779_13330) 2840902..2841180 + 279 WP_003901422.1 type II toxin-antitoxin system VapB family antitoxin -
M1779_RS13335 (M1779_13335) 2841273..2841686 + 414 WP_003413164.1 PIN domain nuclease -
M1779_RS13340 (M1779_13340) 2841725..2841982 + 258 WP_003413167.1 CopG family transcriptional regulator Antitoxin
M1779_RS13345 (M1779_13345) 2841979..2842356 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
M1779_RS13350 (M1779_13350) 2842372..2842746 - 375 WP_003413177.1 hypothetical protein -
M1779_RS13355 (M1779_13355) 2842846..2843241 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
M1779_RS13360 (M1779_13360) 2843238..2843483 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
M1779_RS13365 (M1779_13365) 2843894..2844313 - 420 WP_003413190.1 A24 family peptidase -
M1779_RS13370 (M1779_13370) 2844325..2845133 - 809 Protein_2639 shikimate dehydrogenase -
M1779_RS13375 (M1779_13375) 2845130..2846383 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
M1779_RS13380 (M1779_13380) 2846376..2846888 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T243538 WP_003413174.1 NZ_CP096839:2841979-2842356 [Mycobacterium tuberculosis variant bovis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T243538 NZ_OX359182:c1486748-1486338 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT243538 WP_003413167.1 NZ_CP096839:2841725-2841982 [Mycobacterium tuberculosis variant bovis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT243538 NZ_OX359182:c1486995-1486729 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References