Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2781202..2781854 Replicon chromosome
Accession NZ_CP096839
Organism Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag M1779_RS13055 Protein ID WP_003412752.1
Coordinates 2781429..2781854 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag M1779_RS13050 Protein ID WP_003412749.1
Coordinates 2781202..2781423 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1779_RS13035 (M1779_13035) 2779442..2779648 - 207 WP_079367561.1 hypothetical protein -
M1779_RS13040 (M1779_13040) 2779784..2780407 + 624 WP_003900858.1 TIGR00725 family protein -
M1779_RS13045 (M1779_13045) 2780397..2781149 + 753 WP_003901416.1 hypothetical protein -
M1779_RS13050 (M1779_13050) 2781202..2781423 + 222 WP_003412749.1 antitoxin Antitoxin
M1779_RS13055 (M1779_13055) 2781429..2781854 + 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
M1779_RS13060 (M1779_13060) 2781877..2783058 - 1182 WP_010950729.1 dihydrolipoamide acetyltransferase family protein -
M1779_RS13065 (M1779_13065) 2783055..2784101 - 1047 WP_010950730.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
M1779_RS13070 (M1779_13070) 2784112..2785215 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
M1779_RS13075 (M1779_13075) 2785474..2786295 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
M1779_RS13080 (M1779_13080) 2786292..2786849 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T243535 WP_003412752.1 NZ_CP096839:2781429-2781854 [Mycobacterium tuberculosis variant bovis]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T243535 NZ_OX359175:c5384766-5384383 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT243535 WP_003412749.1 NZ_CP096839:2781202-2781423 [Mycobacterium tuberculosis variant bovis]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT243535 NZ_OX359175:c5385008-5384766 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References