Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 2199234..2199778 | Replicon | chromosome |
| Accession | NZ_CP096839 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb2487 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | G0TLU9 |
| Locus tag | M1779_RS10275 | Protein ID | WP_003409896.1 |
| Coordinates | 2199234..2199530 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P67299 |
| Locus tag | M1779_RS10280 | Protein ID | WP_003409899.1 |
| Coordinates | 2199527..2199778 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1779_RS10220 (M1779_10225) | 2194267..2194617 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| M1779_RS10225 (M1779_10230) | 2194628..2195530 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| M1779_RS10230 (M1779_10235) | 2195551..2195742 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| M1779_RS10235 (M1779_10240) | 2195743..2196039 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| M1779_RS10240 (M1779_10245) | 2196279..2196494 | + | 216 | WP_003409878.1 | antitoxin | - |
| M1779_RS10245 (M1779_10250) | 2196491..2196802 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1779_RS10250 (M1779_10255) | 2196776..2197297 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| M1779_RS10255 (M1779_10260) | 2197272..2197649 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
| M1779_RS10260 (M1779_10265) | 2197691..2198140 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
| M1779_RS10265 (M1779_10270) | 2198137..2198682 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| M1779_RS10270 (M1779_10275) | 2198571..2199185 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| M1779_RS10275 (M1779_10280) | 2199234..2199530 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| M1779_RS10280 (M1779_10285) | 2199527..2199778 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| M1779_RS10285 (M1779_10290) | 2199765..2200259 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| M1779_RS10290 (M1779_10295) | 2200419..2200826 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1779_RS10295 (M1779_10300) | 2200830..2201102 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| M1779_RS10300 (M1779_10305) | 2201135..2202355 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
| M1779_RS10305 (M1779_10310) | 2203254..2203559 | + | 306 | Protein_2036 | ABC transporter permease | - |
| M1779_RS10310 (M1779_10315) | 2203555..2203635 | + | 81 | Protein_2037 | hypothetical protein | - |
| M1779_RS10315 (M1779_10320) | 2203743..2204591 | + | 849 | WP_003409942.1 | class I SAM-dependent methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T243526 WP_003409896.1 NZ_CP096839:c2199530-2199234 [Mycobacterium tuberculosis variant bovis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
>T243526 NZ_OX359175:2027200-2027302 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 84 a.a. Molecular weight: 9207.17 Da Isoelectric Point: 7.0150
>AT243526 WP_003409899.1 NZ_CP096839:c2199778-2199527 [Mycobacterium tuberculosis variant bovis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR
Download Length: 252 bp
>AT243526 NZ_OX359175:c2027309-2027164 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TLU9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BUZ2 |