Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1955013..1955473 Replicon chromosome
Accession NZ_CP096839
Organism Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag M1779_RS09155 Protein ID WP_003408531.1
Coordinates 1955225..1955473 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag M1779_RS09150 Protein ID WP_003408528.1
Coordinates 1955013..1955225 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1779_RS09135 (M1779_09145) 1951491..1952678 - 1188 WP_003898992.1 nitrate transporter NarK -
M1779_RS09140 (M1779_09150) 1952965..1953249 + 285 WP_003408522.1 DUF1876 domain-containing protein -
M1779_RS09145 (M1779_09155) 1953263..1954945 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
M1779_RS09150 (M1779_09160) 1955013..1955225 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1779_RS09155 (M1779_09165) 1955225..1955473 + 249 WP_003408531.1 hypothetical protein Toxin
M1779_RS09160 (M1779_09170) 1955481..1956219 + 739 Protein_1807 hypothetical protein -
M1779_RS09165 (M1779_09175) 1956313..1958013 + 1701 WP_044291081.1 serine/threonine protein kinase PknE -
M1779_RS09170 (M1779_09180) 1958298..1958699 - 402 WP_010950586.1 hypothetical protein -
M1779_RS09175 (M1779_09185) 1958689..1959300 - 612 Protein_1810 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T243523 WP_003408531.1 NZ_CP096839:1955225-1955473 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T243523 NZ_OX359175:686401-686778 [Klebsiella pneumoniae]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGTCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT243523 WP_003408528.1 NZ_CP096839:1955013-1955225 [Mycobacterium tuberculosis variant bovis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT243523 NZ_OX359175:685980-686354 [Klebsiella pneumoniae]
GTGTCAGACACACTCCATGAGACAAATTATCCCAACGACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAATTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References