Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1934281..1934894 Replicon chromosome
Accession NZ_CP096839
Organism Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag M1779_RS09045 Protein ID WP_003408465.1
Coordinates 1934281..1934670 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag M1779_RS09050 Protein ID WP_003408469.1
Coordinates 1934667..1934894 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1779_RS09010 (M1779_09020) 1929911..1930825 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
M1779_RS09015 (M1779_09025) 1930828..1931658 + 831 WP_003408448.1 cyclase family protein -
M1779_RS09020 (M1779_09030) 1931658..1932008 + 351 WP_003898986.1 cupin domain-containing protein -
M1779_RS09025 (M1779_09035) 1932061..1932878 + 818 Protein_1781 3-keto-5-aminohexanoate cleavage protein -
M1779_RS09030 (M1779_09040) 1932892..1933671 + 780 WP_003408460.1 IclR family transcriptional regulator -
M1779_RS09040 (M1779_09050) 1934102..1934233 + 132 Protein_1783 IS3 family transposase -
M1779_RS09045 (M1779_09055) 1934281..1934670 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
M1779_RS09050 (M1779_09060) 1934667..1934894 - 228 WP_003408469.1 antitoxin Antitoxin
M1779_RS09055 (M1779_09065) 1935112..1936596 + 1485 WP_010950580.1 biotin carboxylase -
M1779_RS09060 (M1779_09070) 1936593..1937840 + 1248 WP_003408476.1 serine hydrolase -
M1779_RS09065 (M1779_09075) 1937883..1938302 - 420 WP_003408483.1 hypothetical protein -
M1779_RS09070 (M1779_09080) 1938292..1939002 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T243522 WP_003408465.1 NZ_CP096839:c1934670-1934281 [Mycobacterium tuberculosis variant bovis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T243522 NZ_OX359175:350241-350588 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT243522 WP_003408469.1 NZ_CP096839:c1934894-1934667 [Mycobacterium tuberculosis variant bovis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT243522 NZ_OX359175:350588-350887 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References