Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1684122..1684738 Replicon chromosome
Accession NZ_CP096839
Organism Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag M1779_RS07945 Protein ID WP_003407593.1
Coordinates 1684421..1684738 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag M1779_RS07940 Protein ID WP_003900349.1
Coordinates 1684122..1684424 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1779_RS07930 (M1779_07940) 1680008..1681855 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
M1779_RS07935 (M1779_07945) 1681856..1684108 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
M1779_RS07940 (M1779_07950) 1684122..1684424 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
M1779_RS07945 (M1779_07955) 1684421..1684738 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
M1779_RS07950 (M1779_07960) 1684735..1685739 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
M1779_RS07955 (M1779_07965) 1685792..1687081 + 1290 WP_003407599.1 serine hydrolase domain-containing protein -
M1779_RS07960 (M1779_07970) 1687154..1687771 - 618 WP_003407606.1 class I SAM-dependent methyltransferase -
M1779_RS07965 (M1779_07975) 1687985..1688176 - 192 WP_003407609.1 dodecin family protein -
M1779_RS07970 (M1779_07980) 1688258..1688656 + 399 WP_003900351.1 hypothetical protein -
M1779_RS07975 (M1779_07985) 1688701..1689729 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T243520 WP_003407593.1 NZ_CP096839:1684421-1684738 [Mycobacterium tuberculosis variant bovis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T243520 NZ_OX352996:1759678-1759935 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCCAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT243520 WP_003900349.1 NZ_CP096839:1684122-1684424 [Mycobacterium tuberculosis variant bovis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT243520 NZ_OX352996:1759416-1759676 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References