Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1537673..1538723 Replicon chromosome
Accession NZ_CP096839
Organism Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag M1779_RS07295 Protein ID WP_003407164.1
Coordinates 1537673..1538494 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag M1779_RS07300 Protein ID WP_003407167.1
Coordinates 1538487..1538723 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1779_RS07275 (M1779_07285) 1533231..1533893 - 663 WP_079367497.1 hypothetical protein -
M1779_RS07280 (M1779_07290) 1533890..1534675 - 786 WP_003407157.1 membrane protein -
M1779_RS07285 (M1779_07295) 1534966..1536927 - 1962 WP_010950533.1 sigma-F factor regulator -
M1779_RS07290 (M1779_07300) 1537066..1537452 - 387 WP_003407162.1 anti-sigma-F factor antagonist RsfA -
M1779_RS07295 (M1779_07305) 1537673..1538494 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
M1779_RS07300 (M1779_07310) 1538487..1538723 + 237 WP_003407167.1 hypothetical protein Antitoxin
M1779_RS07305 (M1779_07315) 1538795..1540000 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
M1779_RS07310 (M1779_07320) 1540303..1541088 + 786 WP_003407180.1 lipoprotein LprF -
M1779_RS07315 (M1779_07325) 1541284..1542754 + 1471 Protein_1440 cytochrome b5 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T243518 WP_003407164.1 NZ_CP096839:1537673-1538494 [Mycobacterium tuberculosis variant bovis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T243518 NZ_OX352996:c999821-999639 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAACTTCTTACCGCCAACGGTTGGACAAAGACCAAAGGCGGTAAAGGGTCACA
CGTTAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT243518 WP_003407167.1 NZ_CP096839:1538487-1538723 [Mycobacterium tuberculosis variant bovis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT243518 NZ_OX352996:c999599-999147 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTAGCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAAGGCGAAGATATGGCAAACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGAGATATTCCCATTCCTACCCCTATTAACACCTTATCTTTAGCAGATAATAACCCTTTC
CATGATGATGAGGATATAGAGCTTATCTATGACCCTAGTAAGTCTTTTATTTCTATGGTTATGGTTGATGTTGCCGAGTA
TTTAGGTAGCCAAGAACCTATAAAGAAGACTCTAACTATCCCACGTTGGGCGGATACTTTAGGGCGTGAGCTAGGATTGA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References