Detailed information of TA system TA243517

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1386801..1387360
• Replicon: chromosome
• Accession: NZ_CP096839
• Organism: Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: M1779_RS06640
• Protein ID: WP_003898789.1
• Coordinates: 1386801..1387094 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: M1779_RS06645
• Protein ID: WP_003406322.1
• Coordinates: 1387091..1387360 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1779_RS06615 (M1779_06615)	1382395..1382655	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
M1779_RS06620 (M1779_06620)	1382652..1383083	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
M1779_RS06625 (M1779_06625)	1383106..1384793	-	1688	Protein_1307	PE family protein	-
M1779_RS06630 (M1779_06630)	1384973..1385833	+	861	WP_003406306.1	glycine betaine ABC transporter substrate-binding protein	-
M1779_RS06635 (M1779_06635)	1385914..1386744	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
M1779_RS06640 (M1779_06640)	1386801..1387094	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
M1779_RS06645 (M1779_06645)	1387091..1387360	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
M1779_RS06650 (M1779_06650)	1387473..1391168	-	3696	WP_273585693.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
M1779_RS06655 (M1779_06655)	1391310..1392098	-	789	WP_010950510.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T243517 WP_003898789.1 NZ_CP096839:c1387094-1386801 [Mycobacterium tuberculosis variant bovis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T243517 NZ_OX352996:c997671-997411 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT243517 WP_003406322.1 NZ_CP096839:c1387360-1387091 [Mycobacterium tuberculosis variant bovis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT243517 NZ_OX352996:c997894-997673 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2