Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 751418..752051 Replicon chromosome
Accession NZ_CP096839
Organism Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag M1779_RS03470 Protein ID WP_003403365.1
Coordinates 751418..751801 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag M1779_RS03475 Protein ID WP_003403368.1
Coordinates 751896..752051 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1779_RS03445 (M1779_03445) 746710..747246 + 537 WP_003403341.1 50S ribosomal protein L10 -
M1779_RS03450 (M1779_03450) 747283..747675 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
M1779_RS03455 (M1779_03455) 747668..748363 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
M1779_RS03460 (M1779_03460) 748434..749939 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
M1779_RS03465 (M1779_03465) 750020..751030 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
M1779_RS03470 (M1779_03470) 751418..751801 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
M1779_RS03475 (M1779_03475) 751896..752051 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
M1779_RS03480 (M1779_03480) 752127..752843 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
M1779_RS03485 (M1779_03485) 753119..753427 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
M1779_RS03490 (M1779_03490) 753414..753659 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
M1779_RS03495 (M1779_03495) 753769..754206 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
M1779_RS03500 (M1779_03500) 754203..754457 - 255 WP_003911263.1 antitoxin VapB7 -
M1779_RS03505 (M1779_03505) 754571..756934 + 2364 WP_079367486.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T243506 WP_003403365.1 NZ_CP096839:c751801-751418 [Mycobacterium tuberculosis variant bovis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T243506 NZ_OX352944:485753-486013 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT243506 WP_003403368.1 NZ_CP096839:c752051-751896 [Mycobacterium tuberculosis variant bovis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT243506 NZ_OX352944:485530-485751 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References