Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 714321..714970 Replicon chromosome
Accession NZ_CP096839
Organism Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag M1779_RS03285 Protein ID WP_003403236.1
Coordinates 714575..714970 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag M1779_RS03280 Protein ID WP_003403235.1
Coordinates 714321..714575 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1779_RS03255 (M1779_03255) 709446..709529 + 84 Protein_645 galactose-1-phosphate uridylyltransferase -
M1779_RS03260 (M1779_03260) 709548..710630 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
M1779_RS03265 (M1779_03265) 710627..711718 + 1092 WP_003403225.1 galactokinase -
M1779_RS03270 (M1779_03270) 712113..713270 + 1158 WP_003903091.1 hypothetical protein -
M1779_RS03275 (M1779_03275) 713281..714228 + 948 WP_003403232.1 DUF732 domain-containing protein -
M1779_RS03280 (M1779_03280) 714321..714575 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
M1779_RS03285 (M1779_03285) 714575..714970 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
M1779_RS03290 (M1779_03290) 715064..715804 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
M1779_RS03295 (M1779_03295) 715936..716196 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M1779_RS03300 (M1779_03300) 716193..716600 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
M1779_RS03305 (M1779_03305) 716672..717823 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
M1779_RS03310 (M1779_03310) 717916..719643 - 1728 WP_010950423.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T243504 WP_003403236.1 NZ_CP096839:714575-714970 [Mycobacterium tuberculosis variant bovis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

>T243504 NZ_OX352941:c1620769-1620440 [Streptococcus suis]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT243504 WP_003403235.1 NZ_CP096839:714321-714575 [Mycobacterium tuberculosis variant bovis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp

>AT243504 NZ_OX352941:c1621046-1620759 [Streptococcus suis]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References