Detailed information of TA system TA243502

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 701154..701797
• Replicon: chromosome
• Accession: NZ_CP096839
• Organism: Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P67239
• Locus tag: M1779_RS03200
• Protein ID: WP_003403187.1
• Coordinates: 701396..701797 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ91
• Locus tag: M1779_RS03195
• Protein ID: WP_003403184.1
• Coordinates: 701154..701399 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1779_RS03160 (M1779_03160)	696434..696964	-	531	WP_003917320.1	two component system sensor kinase HK2	-
M1779_RS03165 (M1779_03165)	696948..697643	-	696	WP_197044064.1	two-component system response regulator TcrA	-
M1779_RS03170 (M1779_03170)	697766..698077	+	312	WP_003403164.1	hypothetical protein	-
M1779_RS03175 (M1779_03175)	698149..699099	+	951	WP_003907436.1	DUF1259 domain-containing protein	-
M1779_RS03180 (M1779_03180)	699340..699924	+	585	WP_003403171.1	IS607-like element IS1536 family transposase	-
M1779_RS03185 (M1779_03185)	699926..700636	+	711	Protein_631	IS607 family element RNA-guided endonuclease TnpB	-
M1779_RS03190 (M1779_03190)	700639..701109	+	471	WP_003898523.1	hypothetical protein	-
M1779_RS03195 (M1779_03195)	701154..701399	+	246	WP_003403184.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
M1779_RS03200 (M1779_03200)	701396..701797	+	402	WP_003403187.1	type II toxin-antitoxin system VapC family toxin	Toxin
M1779_RS03205 (M1779_03205)	701788..701967	+	180	Protein_635	hypothetical protein	-
M1779_RS03210 (M1779_03210)	702385..702582	-	198	WP_003403191.1	hypothetical protein	-
M1779_RS03215 (M1779_03215)	702662..703819	-	1158	WP_003403193.1	hypothetical protein	-
M1779_RS03220 (M1779_03220)	703871..704092	-	222	WP_003898525.1	DUF4926 domain-containing protein	-
M1779_RS03225 (M1779_03225)	704234..704839	+	606	WP_003898526.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-80)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14501.21 Da
• Isoelectric Point: 4.4463

>T243502 WP_003403187.1 NZ_CP096839:701396-701797 [Mycobacterium tuberculosis variant bovis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Nucleotide

• Length: 402 bp

>T243502 NZ_OX352941:c703289-703023 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACCTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTAACTGCCAATCGTTCTGGCC
AATGGCGCTACCGTATCGGCAATTACAGGGTTATCGTCAGCATTGAAGATGACAAATTGATTGTGACAGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8813.12 Da
• Isoelectric Point: 10.3486

>AT243502 WP_003403184.1 NZ_CP096839:701154-701399 [Mycobacterium tuberculosis variant bovis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Nucleotide

• Length: 246 bp

>AT243502 NZ_OX352941:c703524-703273 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Structures

Toxin

• AlphaFold DB: A0A7U4BSD6

Antitoxin

• AlphaFold DB: G0TQ91