Detailed information of TA system TA243501

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/AbrB(antitoxin)
• Location: 695064..695710
• Replicon: chromosome
• Accession: NZ_CP096839
• Organism: Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ88
• Locus tag: M1779_RS03145
• Protein ID: WP_003403137.1
• Coordinates: 695064..695477 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ89
• Locus tag: M1779_RS03150
• Protein ID: WP_003403139.1
• Coordinates: 695474..695710 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1779_RS03125 (M1779_03125)	691147..692697	+	1551	WP_003403119.1	MlaD family protein	-
M1779_RS03130 (M1779_03130)	692749..693141	-	393	WP_003403122.1	type II toxin-antitoxin system toxin ribonuclease C4	-
M1779_RS03135 (M1779_03135)	693138..693395	-	258	WP_003403125.1	type II toxin-antitoxin system antitoxin VapB4	-
M1779_RS03140 (M1779_03140)	693578..694813	-	1236	WP_273585648.1	ATP-binding protein	-
M1779_RS03145 (M1779_03145)	695064..695477	-	414	WP_003403137.1	type II toxin-antitoxin system VapC family toxin	Toxin
M1779_RS03150 (M1779_03150)	695474..695710	-	237	WP_003403139.1	type II toxin-antitoxin system antitoxin VapB27	Antitoxin
M1779_RS03155 (M1779_03155)	695814..696320	-	507	WP_003900973.1	two component system sensor kinase HK1	-
M1779_RS03160 (M1779_03160)	696434..696964	-	531	WP_003917320.1	two component system sensor kinase HK2	-
M1779_RS03165 (M1779_03165)	696948..697643	-	696	WP_197044064.1	two-component system response regulator TcrA	-
M1779_RS03170 (M1779_03170)	697766..698077	+	312	WP_003403164.1	hypothetical protein	-
M1779_RS03175 (M1779_03175)	698149..699099	+	951	WP_003907436.1	DUF1259 domain-containing protein	-
M1779_RS03180 (M1779_03180)	699340..699924	+	585	WP_003403171.1	IS607-like element IS1536 family transposase	-
M1779_RS03185 (M1779_03185)	699926..700636	+	711	Protein_631	IS607 family element RNA-guided endonuclease TnpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-126)

Antitoxin

• SpoVT-AbrB domain (3-43)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 14786.14 Da
• Isoelectric Point: 8.1405

>T243501 WP_003403137.1 NZ_CP096839:c695477-695064 [Mycobacterium tuberculosis variant bovis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Nucleotide

• Length: 414 bp

>T243501 NZ_OX352941:465395-465664 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8212.41 Da
• Isoelectric Point: 5.0351

>AT243501 WP_003403139.1 NZ_CP096839:c695710-695474 [Mycobacterium tuberculosis variant bovis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Nucleotide

• Length: 237 bp

>AT243501 NZ_OX352941:465178-465405 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGTCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Structures

Toxin

• AlphaFold DB: G0TQ88

Antitoxin

• AlphaFold DB: G0TQ89