Detailed information of TA system TA243495

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 363879..364405
• Replicon: chromosome
• Accession: NZ_CP096839
• Organism: Mycobacterium tuberculosis variant bovis strain Mb2487

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: M1779_RS01590
• Protein ID: WP_003401560.1
• Coordinates: 364103..364405 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: P9WJ08
• Locus tag: M1779_RS01585
• Protein ID: WP_003401555.1
• Coordinates: 363879..364106 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1779_RS01570 (M1779_01570)	359527..360330	-	804	WP_003401540.1	Stf0 family sulphotransferase	-
M1779_RS01575 (M1779_01575)	360340..361737	-	1398	WP_003401544.1	sulfatase	-
M1779_RS01580 (M1779_01580)	361916..363736	+	1821	WP_003401546.1	PE family protein	-
M1779_RS01585 (M1779_01585)	363879..364106	+	228	WP_003401555.1	ribbon-helix-helix protein, CopG family	Antitoxin
M1779_RS01590 (M1779_01590)	364103..364405	+	303	WP_003401560.1	toxin-antitoxin system toxin	Toxin
M1779_RS01595 (M1779_01595)	364453..364674	+	222	WP_003401563.1	type II toxin-antitoxin system antitoxin VapB2	-
M1779_RS01600 (M1779_01600)	364671..365096	+	426	WP_003401566.1	PIN domain nuclease	-
M1779_RS01605 (M1779_01605)	365232..365864	+	633	WP_003401571.1	TetR/AcrR family transcriptional regulator	-
M1779_RS01610 (M1779_01610)	365861..366769	+	909	WP_003900117.1	protochlorophyllide reductase	-
M1779_RS01615 (M1779_01615)	366777..367367	-	591	WP_234712434.1	hypothetical protein	-
M1779_RS01620 (M1779_01620)	367360..367410	-	51	Protein_320	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10442.16 Da
• Isoelectric Point: 4.9609

>T243495 WP_003401560.1 NZ_CP096839:364103-364405 [Mycobacterium tuberculosis variant bovis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Nucleotide

• Length: 303 bp

>T243495 NZ_OX352940:1758544-1758873 [Streptococcus suis]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8130.21 Da
• Isoelectric Point: 7.0084

>AT243495 WP_003401555.1 NZ_CP096839:363879-364106 [Mycobacterium tuberculosis variant bovis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Nucleotide

• Length: 228 bp

>AT243495 NZ_OX352940:1758267-1758554 [Streptococcus suis]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4F8T1