Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 49586..50108 Replicon plasmid pPS10-3-tetX
Accession NZ_CP096838
Organism Escherichia coli strain PS10-3

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag MYF74_RS22935 Protein ID WP_000220560.1
Coordinates 49827..50108 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag MYF74_RS22930 Protein ID WP_000121743.1
Coordinates 49586..49837 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYF74_RS22905 (MYF74_22905) 45257..45538 + 282 WP_001185482.1 hypothetical protein -
MYF74_RS22910 (MYF74_22910) 45563..46540 + 978 WP_024245156.1 hypothetical protein -
MYF74_RS22915 (MYF74_22915) 46537..46893 - 357 WP_000456533.1 DNA distortion polypeptide 3 -
MYF74_RS22920 (MYF74_22920) 47030..47476 - 447 Protein_46 hypothetical protein -
MYF74_RS22925 (MYF74_22925) 47516..48352 - 837 WP_001050931.1 RepB family plasmid replication initiator protein -
MYF74_RS22930 (MYF74_22930) 49586..49837 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
MYF74_RS22935 (MYF74_22935) 49827..50108 + 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYF74_RS22940 (MYF74_22940) 50183..50880 + 698 WP_103215986.1 IS1-like element IS1A family transposase -
MYF74_RS22945 (MYF74_22945) 50890..51198 + 309 Protein_51 replication initiation protein -
MYF74_RS22950 (MYF74_22950) 52786..53754 + 969 WP_030005799.1 IS5 family transposase -
MYF74_RS22955 (MYF74_22955) 53894..54280 - 387 WP_001039464.1 plasmid stabilization protein StbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / qnrS1 / blaTEM-1B / sul3 / tet(A) / floR / tet(X4) / dfrA14 - 1..54649 54649


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T243493 WP_000220560.1 NZ_CP096838:49827-50108 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T243493 NZ_OX352940:c997666-997406 [Streptococcus suis]
ATGTATCATTTAGAGTATTCTAAAAAGGCTCAAAAGCAAATTATGAAATTAGATAGGCAAATTCAGAGGCTGTTGTTTGC
TTGGATTGATAAACACTTAGAAGGGACTGATAATCCACGCGCCAATGGTAAAGGTTTGACAGGCAATCATGCTAACGAGT
GGCGTTATCGTATCGGAGATTACCGACTGATTTGCGATATTCAAGATGATAAGTTGGTTATTTTAGCACTTGAGTTTGGA
CATCGTAAAGATGTCTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT243493 WP_000121743.1 NZ_CP096838:49586-49837 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp

>AT243493 NZ_OX352940:c997889-997668 [Streptococcus suis]
ATGAGTACAGTGACAATCAGATTAAATCAAGAAGAAGAAGTATTCTTTAAAAGCTATGCACAATTAACAGGTCAAAGTCT
TTCTAGCCTTTTTAAGAAAGCTTTGGAGCGTGATATTGAAGATGAGTATGATTTAAAAATCTATCATCAAGCTTATGATG
AGTACAAAGCAGATCCAGAAACAATTAGTCATGCTGATTTTAAGAAAGAGCTAGGATTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References