Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4247259..4247854 Replicon chromosome
Accession NZ_CP096837
Organism Escherichia coli strain PS10-3

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag MYF74_RS19940 Protein ID WP_000239579.1
Coordinates 4247259..4247609 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag MYF74_RS19945 Protein ID WP_001223208.1
Coordinates 4247603..4247854 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYF74_RS19920 (4242705) 4242705..4243727 - 1023 WP_248748127.1 ABC transporter permease -
MYF74_RS19925 (4243741) 4243741..4245243 - 1503 WP_248748128.1 sugar ABC transporter ATP-binding protein -
MYF74_RS19930 (4245383) 4245383..4246339 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
MYF74_RS19935 (4246649) 4246649..4247179 + 531 WP_000055072.1 inorganic diphosphatase -
MYF74_RS19940 (4247259) 4247259..4247609 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
MYF74_RS19945 (4247603) 4247603..4247854 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
MYF74_RS19950 (4248066) 4248066..4248407 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
MYF74_RS19955 (4248410) 4248410..4252189 - 3780 WP_053274060.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T243491 WP_000239579.1 NZ_CP096837:c4247609-4247259 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T243491 NZ_OX352940:c800579-799803 [Streptococcus suis]
ATGAGATTGGAAGAATTTAGTGAGGAAGAGTTTCAGAAGGCCTTGCAGCGAACTATTAGGGCCCAAAGTCGTGGGAAGAC
GATTCCAAATCAACCGAGAGCCATTTTACTTGGAGGTCAGAGCGGAGCAGGTAAGACGACTATTCATCGAATTAAACAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAATTACTTAGCCTTGCAAGAT
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGAACTCAGCAC
GCAGGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGTTACCAAGTTTCCTTAGCAGTGATTGGCACCAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCCATCGATCCCAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAAGGAGCTTGAAAGCGATAAACTCTTTGACCAAATTCAGATTTATCAAAGAGATCGAACTTGTATCTACGATTCTG
AAACTGATGAAGGCTCCGCAGCAGAGGTTCTTCAAAACTGTCTTTTCGGGAAGTGGAGTAAGGTTGAGGAAGAGATGTTG
AAGGTAGGACAGGAACGGTTGGGGGAATTAGTTTCAGCTAATGGAGAGAAGAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT243491 WP_001223208.1 NZ_CP096837:c4247854-4247603 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT243491 NZ_OX352940:c801055-800579 [Streptococcus suis]
ATGATTGGAGACAACATCAAGTCACTACGTCGGACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCTTAAGTCGTTATGAAAATGGAACCAGCACCGTATCAACAGAACTCATCGACCGCATTTGTCAAAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAAGATAGTCAAGACATCGCCTTTGATGATGA
ATCGAATCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACACGAAAATTTACCTTGTCGATACCTTCGATG
AAATAGAGCGCTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATTGGGTGGTGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References