Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3539046..3539664 Replicon chromosome
Accession NZ_CP096837
Organism Escherichia coli strain PS10-3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag MYF74_RS16735 Protein ID WP_001291435.1
Coordinates 3539446..3539664 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag MYF74_RS16730 Protein ID WP_000344800.1
Coordinates 3539046..3539420 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYF74_RS16720 (3534135) 3534135..3535328 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MYF74_RS16725 (3535351) 3535351..3538500 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
MYF74_RS16730 (3539046) 3539046..3539420 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
MYF74_RS16735 (3539446) 3539446..3539664 + 219 WP_001291435.1 HHA domain-containing protein Toxin
MYF74_RS16740 (3539836) 3539836..3540387 + 552 WP_000102564.1 maltose O-acetyltransferase -
MYF74_RS16745 (3540503) 3540503..3540973 + 471 WP_000136192.1 YlaC family protein -
MYF74_RS16750 (3541137) 3541137..3542687 + 1551 WP_001362407.1 cyclic-guanylate-specific phosphodiesterase PdeB -
MYF74_RS16755 (3542729) 3542729..3543082 - 354 WP_000878140.1 DUF1428 domain-containing protein -
MYF74_RS16765 (3543461) 3543461..3543772 + 312 WP_000409911.1 MGMT family protein -
MYF74_RS16770 (3543803) 3543803..3544375 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T243488 WP_001291435.1 NZ_CP096837:3539446-3539664 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T243488 NZ_OX352831:c1956310-1955981 [Streptococcus suis]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTGGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT243488 WP_000344800.1 NZ_CP096837:3539046-3539420 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT243488 NZ_OX352831:c1956587-1956300 [Streptococcus suis]
TTGATAACTATAAATAAAGATGCCCAAGTAAATTTTAAAACTGATTCCAGACTTTTAGAAAAAGCCAAGGAAGTATTTGC
TATGAACCAGCTGGATTTGACTGCTGGTTTTAACCTCTTCTTGCAAAATATCGCTGTAAAAAATGAGTTGCCAATTCTGA
CAGAAGAAGAGTTGGAAAGAGAAGAGTTGTTTTTACAGTTACAGAAGGAAATCCAGGAAAACCAACAGGCGATTGAGGCA
GGTCACGGGATCAGCCTAGAAAGTGTCAAAGAGAAGTATGGAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References