Detailed information of TA system TA243486

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/UPF0150(antitoxin)
• Location: 2436614..2437252
• Replicon: chromosome
• Accession: NZ_CP096837
• Organism: Escherichia coli strain PS10-3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A080J2T0
• Locus tag: MYF74_RS11510
• Protein ID: WP_000813793.1
• Coordinates: 2437076..2437252 (-)
• Length: 59 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MYF74_RS11505
• Protein ID: WP_001270286.1
• Coordinates: 2436614..2437030 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYF74_RS11485 (2431766)	2431766..2432707	-	942	WP_001251315.1	ABC transporter permease	-
MYF74_RS11490 (2432708)	2432708..2433721	-	1014	WP_000220411.1	ABC transporter ATP-binding protein	-
MYF74_RS11495 (2433739)	2433739..2434884	-	1146	WP_000047424.1	ABC transporter substrate-binding protein	-
MYF74_RS11500 (2435129)	2435129..2436535	-	1407	WP_000760655.1	PLP-dependent aminotransferase family protein	-
MYF74_RS11505 (2436614)	2436614..2437030	-	417	WP_001270286.1	type II toxin-antitoxin system antitoxin HicB	Antitoxin
MYF74_RS11510 (2437076)	2437076..2437252	-	177	WP_000813793.1	type II toxin-antitoxin system mRNA interferase toxin HicA	Toxin
MYF74_RS11515 (2437474)	2437474..2437704	+	231	WP_000494244.1	YncJ family protein	-
MYF74_RS11520 (2437796)	2437796..2439757	-	1962	WP_053273748.1	23S rRNA 5-hydroxycytidine C2501 synthase	-
MYF74_RS11525 (2439830)	2439830..2440366	-	537	WP_023307966.1	DNA-binding transcriptional regulator SutR	-
MYF74_RS11530 (2440458)	2440458..2441633	+	1176	WP_053273747.1	BenE family transporter YdcO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2441673..2442821	1148

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• Cro/C1-type helix-turn-helix domain (91-134)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6724.83 Da
• Isoelectric Point: 10.9223

>T243486 WP_000813793.1 NZ_CP096837:c2437252-2437076 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGMRSVMPRHPCDEIKEPLRKAILKQLGLS

Nucleotide

• Length: 177 bp

>T243486 NZ_OX352831:c1037362-1037096 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACCTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTAACTGCCAATCGTTCTGGCC
AATGGCGCTACCGTATCGGCAATTACAGGGTTATCGTCAGCATTGAAGATGACAAATTGATTGTGACAGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15246.63 Da
• Isoelectric Point: 4.7386

>AT243486 WP_001270286.1 NZ_CP096837:c2437030-2436614 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Nucleotide

• Length: 417 bp

>AT243486 NZ_OX352831:c1037597-1037346 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Structures

Toxin

• AlphaFold DB: A0A080J2T0