Detailed information of TA system TA243485

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2341637..2343225
• Replicon: chromosome
• Accession: NZ_CP096837
• Organism: Escherichia coli strain PS10-3

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MYF74_RS11110
• Protein ID: WP_187205732.1
• Coordinates: 2341903..2343225 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MYF74_RS11105
• Protein ID: WP_137567394.1
• Coordinates: 2341637..2341903 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYF74_RS11105 (2341637)	2341637..2341903	+	267	WP_137567394.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MYF74_RS11110 (2341903)	2341903..2343225	+	1323	WP_187205732.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
MYF74_RS11115 (2343496)	2343496..2343765	+	270	Protein_2182	AraC family transcriptional regulator	-
MYF74_RS11120 (2344199)	2344199..2344762	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
MYF74_RS11125 (2345123)	2345123..2345833	+	711	WP_001195165.1	fimbria/pilus periplasmic chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49376.03 Da
• Isoelectric Point: 8.8752

>T243485 WP_187205732.1 NZ_CP096837:2341903-2343225 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRRGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALVVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Nucleotide

• Length: 1323 bp

>T243485 NZ_OX352831:799468-799737 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10017.36 Da
• Isoelectric Point: 4.9632

>AT243485 WP_137567394.1 NZ_CP096837:2341637-2341903 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTSLTTFFKILQSLELSMTLCDTKNASPEA
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT243485 NZ_OX352831:799251-799478 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGTCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA