Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1167273..1167931 Replicon chromosome
Accession NZ_CP096837
Organism Escherichia coli strain PS10-3

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag MYF74_RS05565 Protein ID WP_097512823.1
Coordinates 1167273..1167593 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag MYF74_RS05570 Protein ID WP_063622306.1
Coordinates 1167614..1167931 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYF74_RS05560 (1162373) 1162373..1166953 + 4581 WP_248748219.1 adhesin-like autotransporter YpjA/EhaD -
MYF74_RS05565 (1167273) 1167273..1167593 - 321 WP_097512823.1 TA system toxin CbtA family protein Toxin
MYF74_RS05570 (1167614) 1167614..1167931 - 318 WP_063622306.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MYF74_RS05575 (1167949) 1167949..1168170 - 222 WP_038434455.1 DUF987 domain-containing protein -
MYF74_RS05580 (1168179) 1168179..1168661 - 483 WP_097512822.1 DNA repair protein RadC -
MYF74_RS05585 (1168670) 1168670..1169128 - 459 WP_097512821.1 antirestriction protein -
MYF74_RS05590 (1169234) 1169234..1169449 - 216 Protein_1098 DUF905 domain-containing protein -
MYF74_RS05595 (1169527) 1169527..1169937 - 411 WP_097512820.1 hypothetical protein -
MYF74_RS05600 (1170004) 1170004..1170441 - 438 WP_097512819.1 hypothetical protein -
MYF74_RS05605 (1170483) 1170483..1170992 - 510 WP_097512818.1 DUF4339 domain-containing protein -
MYF74_RS05610 (1171018) 1171018..1171728 - 711 WP_097512817.1 DeoR family transcriptional regulator -
MYF74_RS05615 (1171937) 1171937..1172761 - 825 WP_097512816.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1160043..1190181 30138


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-102)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12085.19 Da        Isoelectric Point: 9.7207

>T243476 WP_097512823.1 NZ_CP096837:c1167593-1167273 [Escherichia coli]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLRQHYGLTLNDTPFSNETVIKEHIDAGISLVDAVNFLVEKYELARIDSKGF
SWQEQSPFITAVDILKARRAMREMRI

Download         Length: 321 bp

>T243476 NZ_OX352806:769556-770332 [Streptococcus suis]
ATGAGATTGGAAGAATTTAGTGAGGAAGAGTTTCAGAAGGCCTTGCAGCGAACTATTAGGGCCCAAAGTCGTGGGAAGAC
GATTCCAAATCAACCGAGAGCCATTTTACTTGGAGGTCAGAGCGGAGCAGGTAAGACGACTATTCATCGAATTAAACAAA
AAGAATTTCAAGGTAATATCATTATCATCGATGGTGATAGCTACCGTTCTCAGCATCCCAATTACTTAGCCTTGCAAGAT
AAGTATGGCAAGGACAGCGTGGACTATACCAAGGGATTTGCAGGAAAAATGGTAGAGCATCTGGTTGACGAACTCAGCAC
GCAGGGTTATCATTTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTATCTTCTA
AAGGTTACCAAGTTTCCTTAGCAGTGATTGGCACCAAACCAGAGCTTTCTTATCTCAGCACCTTGATTCGTTACGAAGAA
CTTTATGCCATCGATCCCAATCAGGCTAGAGCAACACCAAAAGAACACCATGATGGGATTGTAGAGAACTTGGTTGATAA
CCTAAAGGAGCTTGAAAGCGATAAACTCTTTGACCAAATTCAGATTTATCAAAGAGATCGAACTTGTATCTACGATTCTG
AAACTGATGAAGGCTCCGCAGCAGAGGTTCTTCAAAACTGTCTTTTCGGGAAGTGGAGTAAGGTTGAGGAAGAGATGTTG
AAGGTAGGACAGGAACGGTTGGGGGAATTAGTTTCAGCTAATGGAGAGAAGAAATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11762.32 Da        Isoelectric Point: 6.6193

>AT243476 WP_063622306.1 NZ_CP096837:c1167931-1167614 [Escherichia coli]
MSNTTWGLQRDITPCLGARLVQEGNRLHYLDDRASITGKFSDAQCIKLDVVFPHFISQIESVLTTGELNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 318 bp

>AT243476 NZ_OX352806:769080-769556 [Streptococcus suis]
ATGATTGGAGACAACATCAAGTCACTACGTCGGACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCTTAAGTCGTTATGAAAATGGAACCAGCACCGTATCAACAGAACTCATCGACCGCATTTGTCAAAAATTTA
ACGTTTCTTATGTCGATATTGTAGGAGAGGACAAGATGTTAACACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATAAAAGAACGTGGAGCAGCCATTTTATCACAGCTTTATAGATACCAAGATAGTCAAGACATCGCCTTTGATGATGA
ATCGAATCCTTGGATTTTGATGAGTGATGACTTGGCCGAATTGATTAACACGAAAATTTACCTTGTCGATACCTTCGATG
AAATAGAGCGCTACAATGGCTATTTAGACGGTATCGAGCGGATGTTAGACATGGTGCATCATTGGGTGGTGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References