Detailed information of TA system TA243445

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 389860..391448
• Replicon: chromosome
• Accession: NZ_CP096834
• Organism: Escherichia coli strain PM4-5

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: F4NFZ0
• Locus tag: MYF75_RS03635
• Protein ID: WP_001125463.1
• Coordinates: 390126..391448 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MYF75_RS03630
• Protein ID: WP_001296726.1
• Coordinates: 389860..390126 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYF75_RS03630 (389860)	389860..390126	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MYF75_RS03635 (390126)	390126..391448	+	1323	WP_001125463.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
MYF75_RS03640 (391760)	391760..391968	+	209	Protein_397	AraC family transcriptional regulator	-
MYF75_RS03645 (392402)	392402..392965	+	564	WP_001296758.1	type 1 fimbrial major subunit FimA	-
MYF75_RS03650 (393326)	393326..394036	+	711	WP_001195166.1	fimbria/pilus periplasmic chaperone	-
MYF75_RS03655 (394078)	394078..394857	+	780	Protein_400	FimD/PapC N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49422.05 Da
• Isoelectric Point: 9.1203

>T243445 WP_001125463.1 NZ_CP096834:390126-391448 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Nucleotide

• Length: 1323 bp

>T243445 NZ_OX352319:c1277124-1276942 [Pseudomonas sp. MM227]
ATGAGCTGTAACGAGTTCAAGCGGTGGCTGCTAGCACAAGGAGTGGAAATCTCGAAGCAACGTAGTAAGCACTTCAAGAT
CTTCTACAACGGCAAGCAGACGGTACTTCCAGACCACGGAGCCAAGGAAATAGGCGAAGGACTCAGGAAGACGATCATCA
AACAACTGGGCCTCAAGGACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT243445 WP_001296726.1 NZ_CP096834:389860-390126 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT243445 NZ_OX352319:c1276891-1276469 [Pseudomonas sp. MM227]
ATGTTCAGCTATGCAATAAAGGTTCACGCGGAGGCCGGCTCCTTTTGGTCTTCGTGCCGCGATATCCCCGAGGCGCACAG
CGCCGGTGATACAGAGGAAGAACTGCTGGCCAATGCCGTTGAAGGCCTTGAGCTGGCTTTGACCATTTACGTGGATCAAT
CTCGTCCGATCCCTCTACCCTCGGCGCCTGTCAAGGGCGAGCGCGTTGTGCATCTGCCGACCTTGCTGGCCGCAAAGGTT
TCGCTCTGGAACGCTATGCGTGAGGCGAATATGCGCAAAGCCGATCTGGCTAGGCTGCTTCAGTCGTCGCAGACCAAGGT
TGATCGCCTTTTGGACTTCGAACACAGCTCGAAGATCGAGCAAGTCGAAGCCGCGCTTGCGGCCCTGGGTAAACGCCTGG
CCGTCTCGGTCGAGGCTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A7U9IYX0