Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2248833..2249808 Replicon chromosome
Accession NZ_CP096827
Organism Bacillus anthracis strain CVCC40205

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag M1D19_RS11875 Protein ID WP_002036394.1
Coordinates 2249071..2249808 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag M1D19_RS11870 Protein ID WP_000588712.1
Coordinates 2248833..2248958 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1D19_RS11835 (M1D19_11805) 2244587..2245057 + 471 WP_000670597.1 DUF5065 family protein -
M1D19_RS11840 (M1D19_11810) 2245621..2247090 - 1470 WP_000287522.1 beta-Ala-His dipeptidase -
M1D19_RS11845 (M1D19_11815) 2247234..2247410 - 177 WP_000808045.1 stage II sporulation protein SB -
M1D19_RS11850 2247487..2247612 - 126 WP_000694311.1 hypothetical protein -
M1D19_RS11855 (M1D19_11820) 2247749..2247985 + 237 WP_001021689.1 hypothetical protein -
M1D19_RS11860 (M1D19_11825) 2248262..2248543 + 282 WP_001041555.1 hypothetical protein -
M1D19_RS11865 (M1D19_11830) 2248580..2248756 - 177 WP_000852614.1 hypothetical protein -
M1D19_RS11870 (M1D19_11835) 2248833..2248958 - 126 WP_000588712.1 hypothetical protein Antitoxin
M1D19_RS11875 (M1D19_11840) 2249071..2249808 - 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M1D19_RS11880 (M1D19_11845) 2249997..2250734 - 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
M1D19_RS11885 (M1D19_11850) 2250902..2251384 - 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
M1D19_RS11890 (M1D19_11855) 2251491..2253176 + 1686 WP_009879073.1 alpha-keto acid decarboxylase family protein -
M1D19_RS11895 (M1D19_11860) 2253298..2254080 - 783 WP_000381787.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T243432 WP_002036394.1 NZ_CP096827:c2249808-2249071 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T243432 NZ_OX344719:c180641-180546 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT243432 WP_000588712.1 NZ_CP096827:c2248958-2248833 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT243432 NZ_OX344719:180459-180518 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References