Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316418..2317393 Replicon chromosome
Accession NZ_CP096824
Organism Bacillus anthracis strain CVCC40202

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag M1C60_RS12120 Protein ID WP_002036394.1
Coordinates 2316418..2317155 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag M1C60_RS12125 Protein ID WP_000588712.1
Coordinates 2317268..2317393 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1C60_RS12100 (M1C60_12080) 2312146..2312928 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
M1C60_RS12105 (M1C60_12085) 2313050..2314735 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
M1C60_RS12110 (M1C60_12090) 2314842..2315324 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
M1C60_RS12115 (M1C60_12095) 2315492..2316229 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
M1C60_RS12120 (M1C60_12100) 2316418..2317155 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M1C60_RS12125 (M1C60_12105) 2317268..2317393 + 126 WP_000588712.1 hypothetical protein Antitoxin
M1C60_RS12130 (M1C60_12110) 2317470..2317646 + 177 WP_000852614.1 hypothetical protein -
M1C60_RS12135 (M1C60_12115) 2317683..2317964 - 282 WP_001041555.1 hypothetical protein -
M1C60_RS12140 (M1C60_12120) 2318241..2318477 - 237 WP_001021689.1 hypothetical protein -
M1C60_RS12145 2318614..2318739 + 126 WP_000694311.1 hypothetical protein -
M1C60_RS12150 (M1C60_12125) 2318816..2318992 + 177 WP_000808045.1 stage II sporulation protein SB -
M1C60_RS12155 (M1C60_12130) 2319136..2320605 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
M1C60_RS12160 (M1C60_12135) 2321169..2321639 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T243430 WP_002036394.1 NZ_CP096824:2316418-2317155 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T243430 NZ_OX344719:20011-20187 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT243430 WP_000588712.1 NZ_CP096824:2317268-2317393 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT243430 NZ_OX344719:c20349-20175 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References