Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 240781..241423 Replicon chromosome
Accession NZ_CP096824
Organism Bacillus anthracis strain CVCC40202

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag M1C60_RS01340 Protein ID WP_000635963.1
Coordinates 241073..241423 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag M1C60_RS01335 Protein ID WP_000004570.1
Coordinates 240781..241068 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1C60_RS01310 (M1C60_01310) 236097..237059 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
M1C60_RS01315 (M1C60_01315) 237052..237624 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
M1C60_RS01320 (M1C60_01320) 237717..238076 + 360 WP_000635040.1 holo-ACP synthase -
M1C60_RS01325 (M1C60_01325) 238233..239183 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
M1C60_RS01330 (M1C60_01330) 239302..240471 + 1170 WP_000390596.1 alanine racemase -
M1C60_RS01335 (M1C60_01335) 240781..241068 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
M1C60_RS01340 (M1C60_01340) 241073..241423 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
M1C60_RS01345 (M1C60_01345) 241491..243659 + 2169 WP_000426225.1 Tex family protein -
M1C60_RS01350 (M1C60_01350) 243717..243833 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
M1C60_RS01355 (M1C60_01355) 244029..244487 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T243429 WP_000635963.1 NZ_CP096824:241073-241423 [Bacillus anthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T243429 NZ_OX337253:55122-55604 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT243429 WP_000004570.1 NZ_CP096824:240781-241068 [Bacillus anthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT243429 NZ_OX337253:54868-55134 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References