243424

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3707385..3708606 Replicon chromosome
Accession NZ_CP096822
Organism Pseudomonas aeruginosa strain NY8709

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M1V28_RS16905 Protein ID WP_003114949.1
Coordinates 3708028..3708606 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M1V28_RS16900 Protein ID WP_003088112.1
Coordinates 3707385..3707939 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1V28_RS16875 (M1V28_16845) 3702953..3703504 + 552 WP_003132721.1 XRE family transcriptional regulator -
M1V28_RS16880 (M1V28_16850) 3703501..3703899 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
M1V28_RS16885 (M1V28_16855) 3703912..3704235 - 324 WP_003102734.1 multidrug efflux SMR transporter -
M1V28_RS16890 (M1V28_16860) 3704566..3705027 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
M1V28_RS16895 (M1V28_16865) 3705032..3707227 + 2196 WP_003450155.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
M1V28_RS16900 (M1V28_16870) 3707385..3707939 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
M1V28_RS16905 (M1V28_16875) 3708028..3708606 + 579 WP_003114949.1 HD domain-containing protein Toxin
M1V28_RS16910 (M1V28_16880) 3708714..3709901 - 1188 WP_019726106.1 HlyD family efflux transporter periplasmic adaptor subunit -
M1V28_RS16915 (M1V28_16885) 3709891..3712062 - 2172 WP_033992638.1 type I secretion system permease/ATPase -
M1V28_RS16920 (M1V28_16890) 3712052..3713329 - 1278 WP_019726104.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T243424 WP_003114949.1 NZ_CP096822:3708028-3708606 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T243424 NZ_OX337252:4071906-4072124 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT243424 WP_003088112.1 NZ_CP096822:3707385-3707939 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT243424 NZ_OX337252:4071505-4071879 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References