Detailed information of TA system TA243420

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4383168..4383693
• Replicon: chromosome
• Accession: NZ_CP096821
• Organism: Pectobacterium sp. 21LCBS03

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MYB54_RS19445
• Protein ID: WP_248721242.1
• Coordinates: 4383168..4383452 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C6D956
• Locus tag: MYB54_RS19450
• Protein ID: WP_005973616.1
• Coordinates: 4383442..4383693 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYB54_RS19425 (MYB54_19425)	4378463..4379695	+	1233	WP_248721241.1	FtsX-like permease family protein	-
MYB54_RS19430 (MYB54_19430)	4379685..4381220	+	1536	WP_080756839.1	SUMF1/EgtB/PvdO family nonheme iron enzyme	-
MYB54_RS19435 (MYB54_19435)	4381243..4381947	+	705	WP_014913963.1	hypothetical protein	-
MYB54_RS19440 (MYB54_19440)	4381958..4382440	+	483	WP_014913962.1	hypothetical protein	-
MYB54_RS19445 (MYB54_19445)	4383168..4383452	-	285	WP_248721242.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MYB54_RS19450 (MYB54_19450)	4383442..4383693	-	252	WP_005973616.1	prevent-host-death protein	Antitoxin
MYB54_RS19455 (MYB54_19455)	4383956..4386283	-	2328	WP_248721243.1	phage/plasmid primase, P4 family	-
MYB54_RS19460 (MYB54_19460)	4386294..4386635	-	342	WP_248721244.1	DUF5375 family protein	-
MYB54_RS19465 (MYB54_19465)	4386632..4386898	-	267	WP_010310714.1	hypothetical protein	-
MYB54_RS19470 (MYB54_19470)	4386895..4387089	-	195	WP_248721988.1	hypothetical protein	-
MYB54_RS19475 (MYB54_19475)	4387082..4387279	-	198	WP_039294701.1	host cell division inhibitor Icd-like protein	-
MYB54_RS19480 (MYB54_19480)	4387315..4387626	-	312	Protein_3812	ash family protein	-
MYB54_RS19485 (MYB54_19485)	4387635..4387859	-	225	WP_248721245.1	hypothetical protein	-
MYB54_RS19490 (MYB54_19490)	4387856..4388116	-	261	WP_248721246.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4377814..4394966	17152

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10994.96 Da
• Isoelectric Point: 10.1716

>T243420 WP_248721242.1 NZ_CP096821:c4383452-4383168 [Pectobacterium sp. 21LCBS03]
MSYKLEFEEHALKEFKKLGAPVREQFTKKLKEILQNPHVPANRLHGMADCYKIKLRSAGYRLVYQVLEHEIVVLVLAVGK
RERSEVYKAAKDRL

Nucleotide

• Length: 285 bp

>T243420 NZ_OX337252:803314-803724 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9079.35 Da
• Isoelectric Point: 5.0807

>AT243420 WP_005973616.1 NZ_CP096821:c4383693-4383442 [Pectobacterium sp. 21LCBS03]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Nucleotide

• Length: 252 bp

>AT243420 NZ_OX337252:803067-803333 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0G4JQP6