Detailed information of TA system TA243419

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 4334806..4335389
• Replicon: chromosome
• Accession: NZ_CP096821
• Organism: Pectobacterium sp. 21LCBS03

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A7V8QAI8
• Locus tag: MYB54_RS19255
• Protein ID: WP_012822278.1
• Coordinates: 4334806..4335111 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MYB54_RS19260
• Protein ID: WP_248721226.1
• Coordinates: 4335099..4335389 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYB54_RS19240 (MYB54_19240)	4331222..4332181	+	960	WP_043901801.1	ABC transporter permease	-
MYB54_RS19245 (MYB54_19245)	4332174..4333040	+	867	WP_248721224.1	ABC transporter permease	-
MYB54_RS19250 (MYB54_19250)	4333037..4334746	+	1710	WP_248721225.1	ABC transporter ATP-binding protein	-
MYB54_RS19255 (MYB54_19255)	4334806..4335111	-	306	WP_012822278.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MYB54_RS19260 (MYB54_19260)	4335099..4335389	-	291	WP_248721226.1	ribbon-helix-helix protein, CopG family	Antitoxin
MYB54_RS19265 (MYB54_19265)	4335451..4336305	-	855	WP_039279287.1	helix-turn-helix domain-containing protein	-
MYB54_RS19270 (MYB54_19270)	4336330..4337169	-	840	WP_014913998.1	HTH-type transcriptional activator RhaS	-
MYB54_RS19275 (MYB54_19275)	4337506..4338996	+	1491	WP_248721227.1	rhamnulokinase	-
MYB54_RS19280 (MYB54_19280)	4338993..4340255	+	1263	WP_248721228.1	L-rhamnose isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-96)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11634.48 Da
• Isoelectric Point: 9.4590

>T243419 WP_012822278.1 NZ_CP096821:c4335111-4334806 [Pectobacterium sp. 21LCBS03]
MPQVIVSERARRDLQRLQDFLKNKNALAAKKAAEVLIRGIRQLEALPNIGRPVEHLPLEYQELVIEFGSSGYVMLYRHDE
LTDRVVILTVKHQKEAGYQNP

Nucleotide

• Length: 306 bp

>T243419 NZ_OX337252:324240-324608 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 11049.16 Da
• Isoelectric Point: 4.9473

>AT243419 WP_248721226.1 NZ_CP096821:c4335389-4335099 [Pectobacterium sp. 21LCBS03]
MADTPRQTTTLRIDQDIKERLKTLADDRHSSAHALMLEAITEYVKREEKRSQYRKEALAAWEEYQSTGEHITADETVTWL
ESWGSGSEQDAPACHK

Nucleotide

• Length: 291 bp

>AT243419 NZ_OX337252:324022-324243 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A7V8QAI8