Detailed information of TA system TA243417

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4100940..4101600
• Replicon: chromosome
• Accession: NZ_CP096821
• Organism: Pectobacterium sp. 21LCBS03

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: MYB54_RS18205
• Protein ID: WP_010301815.1
• Coordinates: 4100940..4101314 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A1D7Z1Z6
• Locus tag: MYB54_RS18210
• Protein ID: WP_005971623.1
• Coordinates: 4101334..4101600 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYB54_RS18180 (MYB54_18180)	4096741..4098069	+	1329	WP_039282120.1	MFS transporter	-
MYB54_RS18185 (MYB54_18185)	4098275..4098661	+	387	WP_039282122.1	thioesterase family protein	-
MYB54_RS18190 (MYB54_18190)	4099000..4099518	+	519	WP_014914178.1	flavodoxin FldB	-
MYB54_RS18195 (MYB54_18195)	4099547..4099870	+	324	WP_205564192.1	hypothetical protein	-
MYB54_RS18200 (MYB54_18200)	4099936..4100871	-	936	WP_039470800.1	23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF	-
MYB54_RS18205 (MYB54_18205)	4100940..4101314	-	375	WP_010301815.1	protein YgfX	Toxin
MYB54_RS18210 (MYB54_18210)	4101334..4101600	-	267	WP_005971623.1	FAD assembly factor SdhE	Antitoxin
MYB54_RS18215 (MYB54_18215)	4101836..4102837	+	1002	WP_248721170.1	tRNA-modifying protein YgfZ	-
MYB54_RS18220 (MYB54_18220)	4102892..4103539	-	648	WP_010279833.1	hemolysin III family protein	-
MYB54_RS18225 (MYB54_18225)	4103970..4104578	+	609	WP_014914174.1	HD domain-containing protein	-
MYB54_RS18230 (MYB54_18230)	4104633..4105637	+	1005	WP_014914173.1	LacI family DNA-binding transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-119)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14654.33 Da
• Isoelectric Point: 10.5560

>T243417 WP_010301815.1 NZ_CP096821:c4101314-4100940 [Pectobacterium sp. 21LCBS03]
MQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQEWQIVKRPWLLKN
GVLLSLQAVNGKDKQQLWLASDSMGDDEWRHLRQILLQQKHWAR

Nucleotide

• Length: 375 bp

>T243417 NZ_OX336137:710930-711214 [Nitrospina watsonii]
ATGAAGATAAAAAAAGTCCGCCATCGAGGATTAAAGCGGTTCATCGAGAAAAACGATCCTAGCGGCCTTCCATCCGCCAA
AGTGGAAAAAGTCCGGGATATTATCACCGCTCTCGTGGTGGCGGAAAGCCCGAATGATTTGCCGGTTTTTCCGGGATGGC
GTCTTCATAGGCTTAAGGGCGACCGCAAAGGCCAATGGAGTATTTCCGTGACCGGCAACTGGCGGATCACCTTTGTACTG
GAAGATGACACGATTCAGGAATTGAATTTGGAGGATTACCACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10507.94 Da
• Isoelectric Point: 5.1392

>AT243417 WP_005971623.1 NZ_CP096821:c4101600-4101334 [Pectobacterium sp. 21LCBS03]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT243417 NZ_OX336137:711214-711507 [Nitrospina watsonii]
ATGAAGAATATAGGAATGATACCCTCACACCCAGGGGAATTTGTCCGGCGGCAGGTGCTGGAGCCGCTTGAATTGTCCAT
CAGCCATGCGGCTGAAATTCTGGACATACGGCGGGCGACTTTATCTGATTTGGTTAACGGAAAAACCAGTTTGACCCCCG
AAATGGCGTTCAGGCTGGAAAAGGCGTTTGATGTAAAAATGGATTTTCTCTTGCGGATGCAGGCACTCTACGATACCGCC
CGCATGCGGCAATCCGGGAAGAACATTGACGTGGTCCGGTTTCATCCAAATTAG

Structures

Antitoxin

• AlphaFold DB: A0A1D7Z1Z6