Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3595262..3595887 Replicon chromosome
Accession NZ_CP096821
Organism Pectobacterium sp. 21LCBS03

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag MYB54_RS16100 Protein ID WP_005976087.1
Coordinates 3595684..3595887 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6D809
Locus tag MYB54_RS16095 Protein ID WP_010282247.1
Coordinates 3595262..3595630 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYB54_RS16080 (MYB54_16080) 3590895..3594023 + 3129 WP_014914543.1 efflux RND transporter permease subunit -
MYB54_RS16085 (MYB54_16085) 3594254..3594502 + 249 WP_014914542.1 type B 50S ribosomal protein L31 -
MYB54_RS16090 (MYB54_16090) 3594520..3594663 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
MYB54_RS16095 (MYB54_16095) 3595262..3595630 + 369 WP_010282247.1 Hha toxicity modulator TomB Antitoxin
MYB54_RS16100 (MYB54_16100) 3595684..3595887 + 204 WP_005976087.1 HHA domain-containing protein Toxin
MYB54_RS16110 (MYB54_16110) 3596753..3597073 + 321 WP_010282239.1 MGMT family protein -
MYB54_RS16115 (MYB54_16115) 3597093..3597674 - 582 WP_014914539.1 YbaY family lipoprotein -
MYB54_RS16120 (MYB54_16120) 3597887..3598750 + 864 WP_014914538.1 acyl-CoA thioesterase II -
MYB54_RS16125 (MYB54_16125) 3598890..3600176 - 1287 WP_185893748.1 ammonium transporter AmtB -
MYB54_RS16130 (MYB54_16130) 3600216..3600554 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T243416 WP_005976087.1 NZ_CP096821:3595684-3595887 [Pectobacterium sp. 21LCBS03]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T243416 NZ_OX336137:c16819-16427 [Nitrospina watsonii]
ATGATTCTGGTGGACACCAGCGTCTGGGTGGATTTTCTGAAAGGTGCGGATTCCCGGGAGCGGCGCGCCCTGCGCCGGCT
CATTGAGGAAGAAGCGGATCTTGCCCTAACGGGTATCATCTTGACAGAAACCCTGCAGGGTATCCGGGAGGACAAGGACT
TTAATAAAGTAAAAGAATCCCTGCTTGCATTCCCCCTTTGCCAGCCAAAGGACTTCGAAACCTACCTGAAAGCGGCGCAG
ATTTACCGGGACTGCCGCAAGCAGGGCAAGACGGTGAGGAAGACCGTCGATTGCCTCATCGCCGCCATCTGCCTGGAACA
CGATCTCATCCTGTTTCACAAGGACCGCAACTTCGACCACATCGCTGACTGCACGGAATTGAAAGTGCTGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14046.80 Da        Isoelectric Point: 4.4787

>AT243416 WP_010282247.1 NZ_CP096821:3595262-3595630 [Pectobacterium sp. 21LCBS03]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT

Download         Length: 369 bp

>AT243416 NZ_OX336137:c17016-16816 [Nitrospina watsonii]
ATGTTACGCACCAATATCGAACTCGACGAAAAACTGGTGAAGGAAGCCATGCGGCTGACCCGCAAGAAAACGAAAAAGGA
ACTGGTGAATTACGCCCTGGAAGAACTCATCACCCGGCGCAAACGGAAAAAACTGCTCGACCTCGAAGGGAAAGTGAAAT
GGACCGGAAAGCTGGATGAGATGCGGAAAGGACGCACATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A086EI31

References