243411

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 5665..6253 Replicon plasmid unnamed1
Accession NZ_CP096819
Organism Acinetobacter baumannii strain Mu1984

Toxin (Protein)


Gene name brnT Uniprot ID A0A3G6Z3M6
Locus tag M1R67_RS19365 Protein ID WP_000438826.1
Coordinates 5665..5952 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag M1R67_RS19370 Protein ID WP_001983304.1
Coordinates 5939..6253 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1R67_RS19335 (M1R67_19325) 944..1519 + 576 WP_001096611.1 plasmid replication DNA-binding protein -
M1R67_RS19340 (M1R67_19330) 1541..1684 + 144 WP_000734097.1 hypothetical protein -
M1R67_RS19345 (M1R67_19335) 1990..2265 + 276 WP_001133626.1 metal/formaldehyde-sensitive transcriptional repressor -
M1R67_RS19350 (M1R67_19340) 2287..3396 + 1110 WP_000842148.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
M1R67_RS19355 (M1R67_19345) 3449..3847 + 399 WP_000235176.1 VOC family protein -
M1R67_RS19360 (M1R67_19350) 4321..5154 + 834 WP_000439570.1 S-formylglutathione hydrolase -
M1R67_RS19365 (M1R67_19355) 5665..5952 + 288 WP_000438826.1 BrnT family toxin Toxin
M1R67_RS19370 (M1R67_19360) 5939..6253 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
M1R67_RS19375 (M1R67_19365) 6381..8793 + 2413 Protein_9 TonB-dependent receptor ZnuD2 -
M1R67_RS19380 (M1R67_19370) 9098..9559 + 462 WP_000761346.1 DIP1984 family protein -
M1R67_RS19385 (M1R67_19375) 9880..10413 - 534 WP_000965055.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..14639 14639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11303.72 Da        Isoelectric Point: 6.0889

>T243411 WP_000438826.1 NZ_CP096819:5665-5952 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T243411 NZ_OX281345:c977869-977483 [Thermococcus nautili]
ATGACTGTCATAGACACCAACGTTTTTCTTTATGCGGTTCTGAAGGACTCGGAGCTCAACGAAGAGGCAAGGAACCTGCT
GGCGTCACTGGAGAGATGGGTCGTTCCGAACATGGTTCTATACGAACTCTACTGGTTTTTGAAGAAGGGGGAGTACTCGG
TGGAAGACATCAATGGGGTAATCTCCGCAGTTCTCTCAAGTCCCAGAACAAAGGTCGTCGGCGACAACGGGAAATACACG
AAGGAAGCCCTGAAGCTGACTAAGAACCCCAAGCGGTTCAACGACATGGTAATTCTTGCAACTGCGAAGGACTTTGGAAG
GCTCGCAACCTATGATAAAAAGCTGAGAAAAGAGGCGGAAAAACTTGGAATCAAAGTGCTACCCTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT243411 WP_001983304.1 NZ_CP096819:5939-6253 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT243411 NZ_OX281345:c978090-977866 [Thermococcus nautili]
ATGAGCCTGACAAAAGTAACTAGAAACTACCAGATTACTATACCAAGCGACGTTAGGAAAAAGCTTGGCATCAAAGTTGG
CGACATACTGCTCGTTGAGGTGGAGGACGGGAAGGTGGTTCTCAAAAAGAGCGAGCTTGAACTTCCACTGCTCCCGGGTG
GAAAGGGGCTGACTGTTGAGGAAATCGAAGAAACCATCATCGAAGGCATCGGTGATGACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G6Z3M6

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References