Detailed information of TA system TA243410

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2458888..2459567
• Replicon: chromosome
• Accession: NZ_CP096818
• Organism: Acinetobacter baumannii strain Mu1984

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7Z1VKH9
• Locus tag: M1R67_RS11870
• Protein ID: WP_000838148.1
• Coordinates: 2459385..2459567 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: M1R67_RS11865
• Protein ID: WP_000966688.1
• Coordinates: 2458888..2459292 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1R67_RS11850 (M1R67_11840)	2455195..2456841	-	1647	WP_003383679.1	phosphoethanolamine--lipid A transferase	-
M1R67_RS11855 (M1R67_11845)	2457146..2458078	+	933	WP_001043692.1	IS5-like element ISAba13 family transposase	-
M1R67_RS11860 (M1R67_11850)	2458279..2458788	-	510	WP_000734512.1	hypothetical protein	-
M1R67_RS11865 (M1R67_11855)	2458888..2459292	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
M1R67_RS11870 (M1R67_11860)	2459385..2459567	-	183	WP_000838148.1	type II toxin-antitoxin system HicA family toxin	Toxin
M1R67_RS11875 (M1R67_11865)	2459893..2460408	-	516	WP_001185594.1	hypothetical protein	-
M1R67_RS11880 (M1R67_11870)	2460478..2461395	-	918	WP_000094259.1	phage tail tube protein	-
M1R67_RS11885 (M1R67_11875)	2461448..2462413	-	966	WP_000002429.1	hypothetical protein	-
M1R67_RS11890 (M1R67_11880)	2462413..2462763	-	351	WP_000065011.1	hypothetical protein	-
M1R67_RS11895 (M1R67_11885)	2462832..2463230	-	399	WP_001251875.1	phage tail terminator-like protein	-
M1R67_RS11900 (M1R67_11890)	2463232..2463600	-	369	WP_000539750.1	hypothetical protein	-
M1R67_RS11905 (M1R67_11895)	2463572..2463979	-	408	WP_000247950.1	hypothetical protein	-
M1R67_RS11910 (M1R67_11900)	2463988..2464356	-	369	WP_002019566.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	plc	2448962..2519837	70875
	-	flank	IS/Tn	-	-	2457146..2458078	932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6677.82 Da
• Isoelectric Point: 10.5523

>T243410 WP_000838148.1 NZ_CP096818:c2459567-2459385 [Acinetobacter baumannii]
VKSLDLIKMIEADSWYEVRVSGSHHHVKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T243410 NZ_OX216966:c6306375-6306040 [Paenibacillus dendritiformis]
TTGACGGTTCCAGGACGTGGCGATTTAGTTTGGCTTAACTTTGATGCGCAAGCCGGATATGAACAGGCAGGCCGGCGGCC
CGCCATTGTGCTGTCCGAAGCCGATTTTAATGAAGTGACCGGCTTTGCGGTTGTATGTCCGATTACAAGCCAAGTTACAA
ATTATCCTTTTGAGGTTCCCCTTCCGGAAGGATTTCCATTTACAGGGGTTGTCCTTACCGATCAATTGAAAAGCCTCGAT
GTAAAAAATCGCAGAATGAAAATCGTGGCGAATATTCATGTAGAATCAGAATGTATGAAAGCTGTGCTTCGCAATGCCCG
GTCTATCCTGGCTTAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT243410 WP_000966688.1 NZ_CP096818:c2459292-2458888 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT243410 NZ_OX216966:c6306641-6306372 [Paenibacillus dendritiformis]
ATGACGACTGCAACGCTCCGTAAATGGGGCAACAGTAGTGCTGTCCGTATTCCGAACCAAATTGTTAAACGTCTTAATCT
GGAAGAAGGCGCGGAAATTGAGCTTATCGTAACTCCGGAAAATGATTTATTGCTTCGCCCTATGAAAAAAGCGCAAGAAT
CGAACGAGGAGTTGCGCGCTCATTTGAAATTGCTTCTTGCAAAAATTAAGCCAGATTCGCCTCGTCATGACGAAGTGGAT
GTAGGAATTGAAGGAGACGAAATGATTTGA

Structures

Toxin

• AlphaFold DB: A0A7Z1VKH9

Antitoxin

• AlphaFold DB: N9L2H6