Detailed information of TA system TA243382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1842925..1844561
• Replicon: chromosome
• Accession: NZ_CP096812
• Organism: Acinetobacter baumannii strain 51248

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: M2A29_RS08750
• Protein ID: WP_284626761.1
• Coordinates: 1842925..1844256 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: M2A29_RS08755
• Protein ID: WP_254946694.1
• Coordinates: 1844253..1844561 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2A29_RS08730 (M2A29_08715)	1839237..1840400	+	1164	WP_272327751.1	hypothetical protein	-
M2A29_RS08735 (M2A29_08720)	1840527..1841498	+	972	WP_272327754.1	5'/3'-nucleotidase SurE	-
M2A29_RS08740 (M2A29_08725)	1841510..1842154	+	645	WP_284626757.1	hypothetical protein	-
M2A29_RS08745 (M2A29_08730)	1842189..1842629	-	441	WP_272337000.1	HD domain-containing protein	-
M2A29_RS08750 (M2A29_08735)	1842925..1844256	+	1332	WP_284626761.1	HipA domain-containing protein	Toxin
M2A29_RS08755 (M2A29_08740)	1844253..1844561	+	309	WP_254946694.1	helix-turn-helix domain-containing protein	Antitoxin
M2A29_RS08760 (M2A29_08745)	1844781..1845212	+	432	WP_227063709.1	hypothetical protein	-
M2A29_RS08765 (M2A29_08750)	1845278..1845541	-	264	WP_039250978.1	Txe/YoeB family addiction module toxin	-
M2A29_RS08770 (M2A29_08755)	1845525..1845788	-	264	WP_272233190.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
M2A29_RS08775 (M2A29_08760)	1846074..1846733	-	660	WP_284626769.1	hypothetical protein	-
M2A29_RS08780 (M2A29_08765)	1846860..1847690	-	831	WP_272233188.1	hypothetical protein	-
M2A29_RS08785 (M2A29_08770)	1847797..1848192	-	396	WP_272233187.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51202.25 Da
• Isoelectric Point: 4.8519

>T243382 WP_284626761.1 NZ_CP096812:1842925-1844256 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELNYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIESDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T243382 NZ_OX030705:6501-6749 [Escherichia coli]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11617.54 Da
• Isoelectric Point: 9.9701

>AT243382 WP_254946694.1 NZ_CP096812:1844253-1844561 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPTE

Nucleotide

• Length: 309 bp

>AT243382 NZ_OX030705:6746-7093 [Escherichia coli]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA